Detail of "101477-55-8"

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Determination of lomerizine in human serum by reversed phase high performance liquid chromatography with solid phase extraction

All Rights Reserved. Determination of lomerizine in human serum by reversed phase high performance liquid chromatography with solid phase extraction. Tang, Jianlin; Zhou, Shiwen; Ying, Yi; Wang, Lu; Huang, Yongpin (Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, Peop. Rep. China). Fenxi Huaxue, 34(7), 995-998 (Chinese) 2006 Kexue Chubanshe. CODEN: FHHHDT. ISSN: 0253-3820. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A reversed phase high performance liq. chromatog. with solid-phase extn. for the detn. of lomerizine (LOZ) concn. in human serum was established. Using flunarizine (FOZ) as an internal std. (IS), solid-phase extn. of human serum with waters oasis HLB column. The Loz and IS were sepd. on C8 column with acetonitrile-water (, 0.2% triethylamine, phosphatic acid adjust pH to 6.5) as the mobile phase, flow rate of 1 mL/min, detected at 223 nm, column temp. at 30°C. The linear range of calibration curve was within drug concns. of 5-320 mg/L (n = 7, r = 0.9998). The lower limit of quantification (S/N = 3) was 5 mg/L. Relative recovery was 99.6%-106.1%, abs. recovery was 61.8%-86.5%. Intra- and inter-assay RSD ranged from 3.6% to 5.3% and 2.7% to 6.In this experiment, several chemicals are used like 101477-55-8 9%, resp. The method can be used for detection of lomerizine concn. in human serum and for estn. of pharmacokinetic parameters. .