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Chemotherapeutic bisamidine derivatives of 6(5H)-phenanthridinone and its pharmaceutically acceptable salts

Chemotherapeutic bisamidine derivatives of 6(5H)-phenanthridinone and its pharmaceutically acceptable salts. Bajwa, Balbir Singh; Chatterjee, Dipak Kumar; Ganguli, Bimal Naresh; DeSouza, John; Reden, Jurgen (Hoechst Pharmaceuticals Ltd., India). Indian IN 153676 A 4 Aug 1984, 17 pp.Several substances like 46794-07-4 may be metioned in this study. (English). (India). CODEN: INXXAP. CLASS: IC: A61K027-00; C07D039-00. APPLICATION: IN 81-BO205 14 Jul 1981. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 63 6(5H)-Phenanthridinone bisamidine derivs. (I where R = H, C1-3 alkyl, C1-3 alkoxy, halogen, nitro, or amine and A = CR1NR2R3 where R1 = H, alkyl, or substituted alkyl and R2 and R3 = H, alkyl, or together part of an heterocyclic group) or their pharmaceutically acceptable salts were prepd. as chemotherapeutic agents. E.g., 3,8-diamino-6(5H)-phenanthridinone [46794-07-4] was reacted with N,N-dimethylacetamide [127-19-5] in the presence of POCl3 and isolated as the HCl to give 3,8-bis(N,N-dimethylaminoethylideneamino)-6(5H)-phenanthridinon e.2HCl [93494-29-2] in 85% yield.In this experiment, several chemicals are used like 46794-07-4 ..

Effects of Proximity on the Relaxation Dynamics of Flindersine and 6(5H)-Phenanthridinone

All Rights Reserved. Effects of Proximity on the Relaxation Dynamics of Flindersine and 6(5H)-Phenanthridinone. Gentili, Pier Luigi; Ortica, Fausto; Romani, Aldo; Favaro, Gianna ( Dipartimento di Chimica, Universita di Perugia, Perugia 06123, Italy). Journal of Physical Chemistry A, 111(2), 193-200 (English) 2007 American Chemical Society. CODEN: JPCAFH. ISSN: 1089-5639. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) Section cross-reference(s): 11, 73, 74 The role played by the carbonyl group in the antenna system of a naturally occurring photochromic chromene, flindersine (FL), has been exptl. investigated and compared with that of a carbonyl group present in a structurally related unreactive heterocyclic compd., 6(5H)-phenanthridinone (PH). Through stationary and time-resolved absorption and emission techniques, the excited-state relaxation dynamics after UV irradn. were detd. for FL and PH. 260-94-6 and 492-22-8 which are cas registry numbers of chemicals are mentioned. The presence of a carbonyl group in both compds. entails the existence of two close-lying, strongly coupled electronic excited states, having n,p* and p,p* character, resp. Their coupling can be modulated by a careful choice of the solvent proticity and temp. Moreover, in the case of strong coupling between the n,p* and p,p* states, we have proved that the relaxation dynamics can involve transitions in which the upper of the coupled states acts as an intermediate for radiationless decay, bypassing the lowest emissive state, whereby the fluorescence quantum yield becomes a function of the excitation wavelength. .