Detail of "101910-24-1"

Reference

The inflammatory response of rabbit skin to topical arachidonic acid and its pharmacological modulation

The inflammatory response of rabbit skin to topical arachidonic acid and its pharmacological modulation. Aked, D.; Foster, S. J.; Howarth, A.; McCormick, M. E.; Potts, H. C. (Pharm. Div., Imp. Chem. Ind. PLC, Macclesfield/Cheshire SK10 4TG, UK). Br. J. 101910-24-1 and 80619-02-9 are cas registry numbers of chemicals which are used as reagents here. Pharmacol., 89(2), 431-8 (English) 1986. CODEN: BJPCBM. ISSN: 0007-1188. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The induction of inflammation by intradermal injection of arachidonic acid [506-32-1] into the rabbit dermis was studied as a potential model for evaluating the anti-inflammatory effects of inhibitors of 5-lipoxygenase [80619-02-9]. Plasma extravasation induced by arachidonic acid was measured by the leakage of 125I-labeled-albumin into the tissues and was dependent on polymorphonuclear leukocyte (PMNL). PMNL infiltration and plasma extravasation into arachidonic acid-injected skin sites was inhibited by the mixed cyclooxygenase-lipoxygenase inhibitor BW755C [66000-40-6]. Arachidonic acid-induced plasma extravasation was inhibited by inhibitors of cyclooxygenase [39391-18-9] and 5-lipoxygenase but not by platelet-activating factor antagonist, kadsurenone. The arachidonic acid inflammation model may be useful for evaluating 5-lipoxygenase inhibitors as potential anti-inflammatory agents for treatment of psoriasis and other inflammatory diseases. .

Effects of a 5-lipoxygenase inhibitor, REV-5901, on leukotriene and histamine release from human lung tissue in vitro

Effects of a 5-lipoxygenase inhibitor, REV-5901, on leukotriene and histamine release from human lung tissue in vitro. Tennant, Carolyn M.Several substances are used for example 101910-24-1 and 80619-02-9 which are their cas registry numbers.; Seale, J. Paul; Temple, Diana M. (Dep. Pharmacol., Univ. Sydney, Sydney 2006, Australia). J. Pharm. Pharmacol., 39(4), 309-11 (English) 1987. CODEN: JPPMAB. ISSN: 0022-3573. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) REV-5901 (I) [101910-24-1] is an arylmethylphenyl ether deriv. which inhibits 5-lipoxygenase [80619-02-9] activity of leukocytes. Its effects on the release of leukotrienes induced by antigen and Ca ionophore from human lung tissue in vitro have been examd. At 1 and 1/ mM, it significantly inhibited the release of leukotrienes induced by both stimuli. At 10 mM, it also inhibited antigen-induced histamine [51-45-6] release. These results suggest that REV-5901 may be useful in clin. disorders such as asthma in which leukotriene release may be involved. .