Detail of "1021-25-6"

Reference

Synthesis and evaluation of two radioiodinated iodoalkenyl-substituted spiroperidol analogs

Synthesis and evaluation of two radioiodinated iodoalkenyl-substituted spiroperidol analogs. McPherson, D. W.; Lisic, E.; Knapp, F. F., Jr.; Ambrose, K. R.; Lambert, C. R.; Kung, M. P.; Kung, H. (Nucl. Med. Group, Oak Ridge Natl. Lab., Oak Ridge, TN 37831-6022, USA). NucCompact, 22(3), 92-4, 96-8 (English) 1991. CODEN: CNNMAC. ISSN: 0344-3752. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 27 The substituted analogs of spiroperidol I (n = 1, 3) were prepd. by iododestannylation of the corresponding tributylstannyl intermediates. No-carrier-added iodine-125-labeled analogs of I were also prepd.Several substances are used for example 1021-25-6 which is its cas registry number. and evaluated in vivo for dopamine D2 receptor uptake. In vivo studies in male mice showed a higher global brain uptake for I (n = 1) (0.13% dose/g) as compared to the uptake of I (n = 2) (0.05 dose/g) after 300 min. I (n = 1) also showed a higher striatum to cerebellum ratio as compared to I (n = 3) after 300 min. .