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Detail of "10212-25-6"

  • CAS Number:
  • 10212-25-6
  • Name:

  • Ancitabine hydrochloride

  • Molecular Structure:
  • Formula:
  • C9H11N3O4.HCl
  • Molecular Weight:
  • 261.69
  • Synonyms:
  • Ancitabine hydrochloride (JAN);2, 2-Anhydroarabinosylcytosine hydrochloride;Cytosine, 1beta-D-arabinofuranosyl-2,2-anhydro-, hydrochloride;Cyclo-cmp hydrochloride;CycloCMP hydrochloride;2,2-Anhydroarabinosylcytosine hydrochloride;O2,2-Cyclocytidine, monohydrochloride;1-beta-D-Arabinofuranosylcytosine, 2,2-anhydro-, hydrochloride;1beta-D-Arabinofuranosylcytosine, 2,2-anhydro-, hydrochloride;2,2-O-Cyclocytidine hydrochloride;2, 2-O-Cyclocytidine hydrochloride;2,2-Anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride;Cyclocytidine hydrochloride;2,2-Anhydrocytarabine hydrochloride;O-2,2-Cyclocytidine monohydrochloride;2,2-Cyclocytidine hydrochloride;6H-Furo(2,3:4,5)oxazolo(3,2-a)-pyrimidine-2-methanol, 2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, monohydrochloride, stereoisomer;1.beta.-D-Arabinofuranosylcytosine, 2, 2-anhydro-, hydrochloride;2, 2-Anhydro-1.beta.-D-arabinofuranosylcytosine hydrochloride;OCTD hydrochloride;2,2-Cyclocytidine, monohydrochloride;2,2-Anhydroaracytidine hydrochloride;Cytosine, 1.beta.-D-arabinofuranosyl-2,2-anhydro-, hydrochloride;2,2'-anhydrocytidine hydrochloride;CyclocytidiniHydrochlorinum;
  • EINECS:
  • 233-515-6
  • Density:
  • 2.01 g/cm3
  • Melting Point:
  • 269-270 °C (dec.)(lit.)
  • Boiling Point:
  • 442 °C at 760 mmHg
  • Flash Point:
  • 221.1 °C
  • Appearance:
  • white fine crystalline powder
  • Safety:
  • 24/25 Details
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CAS No.10212-25-6 Ancitabine hydrochloride

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CAS No.10212-25-6 Ancitabine hydrochloride

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CAS No.10212-25-6 Ancitabine hydrochloride

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CAS No.10212-25-6 Ancitabine hydrochloride

product class Nucleosides 1019 Cyclocytidine hydrochloride CAS 10212-25-6 Molecular formula C9H11N3O4.HCl Molecular weight 261.66

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CAS No.10212-25-6 Ancitabine hydrochloride

Cyclocytidine hydrochloride

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CAS No.10212-25-6 Ancitabine hydrochloride

(-)-Cyclocytidine hydrochloride

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CAS No.10212-25-6 Ancitabine hydrochloride

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Reference

Distribution and excretion of 14C-cyclocytidine in experimental animals
Distribution and excretion of 14C-cyclocytidine in experimental animals. El Dareer, Salah M.; White, Vivian M.; Tillery, Dathleen; Chen, Francis P.; Mellett, L. Bruce; Hill, Donald L. (Kettering-Meyer Lab., South. Res. Inst., Birmingham, Ala., USA). Cancer Treat. Rep., 61(5), 805-14 (English) 1977. CODEN: CTRRDO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The serum levels, tissue distribution, and excretion of 14C-labeled-cyclocytidine-HCl (I-HCl) [10212-25-6] and its products, cytosine arabinoside (araC) [147-94-4] and uracil arabinoside (araU) [3083-77-0], were measured in normal and tumor-bearing mice, rats, dogs, and monkeys given oral, i.p. or i.v. doses. The assay is more sensitive than previously used spectrophotometric procedures. Unchanged I accumulated in the liver, kidneys, and intestines of mice and rats after an i.p. or oral dose; nearly all tissues examd. contained araC and araU. In mice and rats given an i.p. dose of I, the max. serum concn. of the unchanged agent occurred prior to 30 min; after that time, it disappeared from the serum of both species with an apparent half-life of 35 min. For these mice, the serum content of araC remained >0.8 .mu.g/ml for 2 hs. In liver and kidneys of mice, the araC concn. increased and very little araU appeared in the serum and tissues when tetrahydrouridine, an inhibitor of pyrimidine nucleoside deaminase, was given prior to an i.p. dose of I. For mice given an oral dose of I, peak serum levels of the agent occurred at 30 min and 4 h; the serum contained no detectable araC. In rats given I orally, there was a slow rise in the I and araC concn. in serum through 6 h. Following an i.p. dose of I to mice and rats, 70%-95% of the radioactivity was excreted in 24 h; most of this was intact I. Following oral doses of I, 60%-70% of the radioactivity was excreted in 24 h. For dogs and a monkey given an i.v. dose of I, the compd. disappeared from the serum in two phases. The half-lives were 17 and 28 min for the first phase and 125 and 115 min for the second phase, resp. Different amts. of araC appeared in the serum of the two dogs. The dogs and monkey excreted most of the dose in the urine in 24 h. Following an oral dose of I to dogs and a monkey, both I and araC were present in the serum for >12 h. I, and its products were excreted slowly by these animals. This report demonstrates that oral doses of I given to rats, dogs, and monkeys allow potentially therapeutic levels of araC to be attained in serum and tissues. The relatively const. serum and tissue levels of I in these animals for 6 h suggest slow and const. absorption from the gastrointestinal tract. Further evaluation of oral doses is warranted.
Ancitabine hydrochloride
Ancitabine hydrochloride. Neuman, M. (Spain). Med. Actual., 12(8), 303-7 (English/Spanish) 1976. CODEN: MDACAP. DOCUMENT TYPE: Journal; General Review CA Section: 63 (Pharmaceuticals) A review with no refs. on ancitabine-HCl (I) [10212-25-6] including properties, action and uses, side effects, and dosage.
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