Detail of "102691-36-1"

CAS Number:
102691-36-1
Name:
Phosphorodiamidousacid, N,N,N',N'-tetrakis(1-methylethyl)-, 2-cyanoethyl ester
Superlist Name:
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite
Molecular Structure:
Formula:
C₁₅H₃₂N₃OP
Molecular Weight:
301.41
Synonyms:
Phosphorodiamidousacid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester (9CI);2-Cyanoethoxybis(N,N-diisopropylamino)phosphine;2-Cyanoethyltetraisopropylphosphorodiamidite;2-Cyanoethyl-N,N,N1,N1-tetraisopropylphosphorodiamidite;Bis(diisopropylamino)(2-cyanoethoxy)phosphine;Bis(diisopropylamino)-2-cyanoethoxyphosphane;b-CyanoethylN,N,N',N'-tetraisopropylphosphordiamidite;b-Cyanoethyl-N,N,N',N'-tetraisopropyldiamidophosphite;Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester;
Density:
0.949 g/mL at 25 °C(lit.)
Boiling Point:
298.1 °C at 760 mmHg
Flash Point:
177.9 °C
Appearance:
Clear to cloudy colourless liquid
Hazard Symbols:
Xi
Risk Codes:
5-36/37/38
Safety:
3-26-36-24/25-23 Details
Transport Information:
UN 1993 3/PG 3

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Synthesis of oligonucleotides containing an O6-G-alkyl-O6-G inter-strand cross-link: All Rights Reserved. Several substances are used for example 102691-36-1 and 918947-05-4 which are their cas registry numbers. Synthesis of oligonucleotides containing an O6-G-alkyl-O6-G inter-strand cross-link. Wilds, Christopher J.; Booth, Jason D.; Noronha, Anne M. (Department of Chemistry and Biochemistry, Concordia University, Montreal, QC H4B 1R6, Can.). Tetrahedron Letters, 47(51), 9125-9128 (English) 2006 Elsevier Ltd. CODEN: TELEAY. ISSN: 0040-4039. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) A methodol. to synthesize oligonucleotides contg. an alkyl interstrand cross-link between the two O6 atoms of deoxyguanosine has been developed. This cross-link is designed to serve as a stable structural mimic of the lesion formed in duplex DNA with the bifunctional alkylating agent hepsulfam. The O6-alkyl coupling is performed via a Mitsunobu reaction between a nucleoside and mono-protected 1,7-heptanediol. Solid-phase oligonucleotide synthesis using a nucleoside bis-phosphoramidite allows for the assembly of the cross-linked duplex. Sufficient quantities of this cross-linked duplex were obtained for various structural and biol. investigations. .

A convenient method for the direct incorporation of 5-fluoro-2'-deoxycytidine into oligodeoxynucleotides: A convenient method for the direct incorporation of 5-fluoro-2'-deoxycytidine into oligodeoxynucleotides. Marasco, Canio J., Jr.; Sufrin, Janice R. (Grace Cancer Drug Cent., Roswell Park Cancer Inst., Buffalo, NY 14263, USA). J. Org. Chem., 57(23), 6363-5 (English) 1992. CODEN: JOCEAH.Several substances like 102691-36-1 may be metioned in this study. ISSN: 0022-3263. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) A practical and convenient method has been developed for the direct incorporation of 5-fluoro-2'-deoxycytidine into oligodeoxynucleotides. The fact that 5-fluoro-2'-deoxycytidine can be introduced without protection of its exocyclic amino group permits its routine incorporation into oligodeoxynucleotides using std. phosphoramidite chem. via an automated DNA synthesizer. Thus, a title compd. I [X = 4,4'-dimethoxytrityl, Z = P(OCH2CH2CN)N(CHMe2)2] was prepd. in 71% yield. .