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1028307-48-3

Basic Information
CAS No.: 1028307-48-3
Name: 3-[2-[[(2-Methoxyphenyl)Methyl]aMino]ethyl]-2,4(1H,3 H)-quinazolinedione
Molecular Structure:
Molecular Structure of 1028307-48-3 (3-[2-[[(2-Methoxyphenyl)Methyl]aMino]ethyl]-2,4(1H,3 H)-quinazolinedione)
Formula: C18H19N3O3
Molecular Weight: 325.36
Synonyms: 3-{2-[(2-Methoxybenzyl)amino]ethyl}-2,4(1H,3H)-quinazolinedione; 3-[2-[[(2-Methoxyphenyl)methyl]amino]ethyl]-2,4(1H,3H)-quinazolinedione; 3-[2-[[(2-Methoxyphenyl)Methyl]Amino]Ethyl]-2,4(1H,3H)Quinazolinedione
Density: 1.232
PSA: 76.38000
LogP: 2.29140
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 RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.