Reference

Isolation and identification of degradation products of betahistine hydrochloride in drug forms

Isolation and identification of degradation products of betahistine hydrochloride in drug forms. Erguven, H.; Carducci, C. N.; Barsic, G.; Gaozza, C. H. (Fac. Farm. Bioquim., Univ. Buenos Aires, Buenos Aires, Argent.). Rev. Farm. (Buenos Aires), 124(1-12), 33-4 (Spanish) 1982. CODEN: RFABAN. ISSN: 0034-9496. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) After subjecting betahistine-HCl (I-HCl) [5579-84-0] to degrdn. by a) sunlight, b) UV light, c) heating, d) heating with NaOH, e) heating with HCl, or f) H2O2, TLC anal. showed 2-(2-hydroxyethyl)pyridine [103-74-2], MeNH2 [74-89-5], 2-vinylpyridine [100-69-6], and betahistine N-oxide [88796-99-0] as degrdn. products.

Toxicity and hygienic standardization of some pyridylethanols and vinylpyridines

Toxicity and hygienic standardization of some pyridylethanols and vinylpyridines. Bukhalovskii, A. A.; Shugaev, B. B. (USSR). Sb. Nauchn. Tr. - Nauchno-Issled. Inst. Monomerov Sint. Kauch., 5, 81-5 (Russian) 1983. CODEN: STNKDN. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Toxicities of 2- (I) [100-69-6] and 4-vinylpyridine (II) [100-43-6] and 2- (III) [103-74-2], and 4-(b-hydroxyethyl)pyridine (IV) [5344-27-4] were examd. in rats and mice after their administration via stomach and inhalation. The toxicity of II and IV were ~2-fold higher than I and III. The compds. showed polytropic effect on the animals; however, all showed narcotic effect. All 4 showed local irritation of the skin and mucous membrane. Prolonged contact led to dermatitis. II is classified as Class II material (highly toxic) and its safe-exposure ref. level in the working zone is 0.5 mg/m3; III and IV are moderately toxic (class III) and their safe-exposure ref. level is 10 mg/m3.