Detail of "103146-25-4"

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An improved process for preparation of escitalopram

All Rights Reserved. An improved process for preparation of escitalopram.In this study， 71-36-3 and 103146-25-4 are also used. Kaushik, Vipin Kumar; Khan, Mohammed Umar; Meenakshisunderam, Sivakumaran (Aurobindo Pharma Limited, India). PCT Int. Appl. WO 2007012954 A1 1 Feb 2007, 18pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-IB2050 20 Jul 2006. PRIORITY: IN 2005-CH1014 27 Jul 2005. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) The present invention relates to an improved process for the prepn. of escitalopram, which comprises purifn. and optical resoln. of 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethy l)benzonitrile to obtain the S-enantiomer, followed by cyclization to give escitalopram with 99.12% purity. The process has the advantages of high yield and high purity. .