Detail of "10332-51-1"

Reference

Clastogenicity in vitro of the sodium, potassium, calcium, and magnesium salts of saccharin; and of magnesium chloride; consideration of significance

Clastogenicity in vitro of the sodium, potassium, calcium, and magnesium salts of saccharin; and of magnesium chloride; consideration of significance. Ashby, John; Ishidate, Motoi, Jr. (Cent. Toxicol. Lab., Imp. Chem. Ind. PLC, Cheshire, UK). Mutat. Res., 163(1), 63-73 (English) 1986. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) Section cross-reference(s): 4 The Na [128-44-9], K [10332-51-1], Ca [6485-34-3], and Mg [88092-79-9] salts of saccharin, and MgCl2, were clastogenic to Chinese hamster lung fibroblasts in vitro, but only at elevated doses (8-16 mg/mL). Saccharin acid [81-07-2] was inactive to the limits of its soly. (4 mg/mL). When the data are expressed in terms of ionic concn., each salt showed a similar clastogenic potency. Thus, ionic effects induced by these salts in the assay medium may be the crit. determinant of the clastogenic effects seen, rather than the saccharin moiety presenting a genotoxic insult to the chromosomes of the cells. The metal-chelating agents EDTA [60-00-4] and EGTA [67-42-5] were nonclastogenic, but disodium EDTA [139-33-3] showed weak activity prior to toxicity at 0.5 mg/mL. The absence of a clastogenic response to the results of saccharin at doses of <4 mg/mL is discussed within the context of the threshold-dependent tumor-promoting activity of high dose levels of Na saccharin to the bladder of male rats. The doubtful value of conducting in vitro clastogenicity studies at doses of >10-2M is discussed.

Saccharin seed-dressing agents

Saccharin seed-dressing agents. Reinecke, Paul; Heinrich, Guenter (Bayer A.-G. , Fed. Rep. Ger.). Ger. Offen. DE 3534231 A1 2 Apr 1987, 5 pp. (Germany) CODEN: GWXXBX. CLASS: ICM: A01N043-80. 10332-51-1 and 81-07-2 are also in the experiment. ICS: A01C001-08. APPLICATION: DE 85-3534231 26 Sep 1985. DOCUMENT TYPE: Patent CA Section: 5 (Agrochemical Bioregulators) Saccharin and its alkali metal salts are seed-dressing fungicides and bactericides. The fungicidal effectiveness of saccharin (2.5 g/kg) seed dressing against Erysiphe on barley was higher than that of the std. 3-allyloxybenzo[d]-1,2-thiazole 1,1-dioxide. .