Detail of "10344-94-2"

Reference

The effects of phenobarbital pretreatment on the metabolism and acute toxicity of the pesticide parathion in the mouse

The effects of phenobarbital pretreatment on the metabolism and acute toxicity of the pesticide parathion in the mouse. Sultatos, Lester G. (Med. Cent., Louisiana State Univ., New Orleans, LA 70112-1393, USA). Toxicol. Appl. Pharmacol., 86(1), 105-11 (English) 1986. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Single-pass perfusion of mouse livers in situ with parathion (I) [56-38-2] resulted in the formation of the cholinesterase inhibitor paraoxon (PO) [311-45-5], p-nitrophenol (PNP) [100-02-7], p-nitrophenyl sulfate (PNPS) [1080-04-2], and p-nitrophenyl glucuronide (PNPG) [10344-94-2]. Daily pretreatment of mice with i.p. phenobarbital [50-06-6] (80 mg/kg) for 4 days induced hepatic cytochrome P 450 [9035-51-2] content, as well as oxidative activation and oxidative detoxification of I, as measured in vitro. However, phenobarbital pretreatment did not alter prodn. of PO from I in mouse livers perfused in situ, although it increased prodn. of PNP, PNPS, and PNPG. Addnl., phenobarbital pretreatment antagonized the acute toxicity of I in mice. Thus, phenobarbital pretreatment clearly induces that form(s) of cytochrome P 450 catalyzing conversion of I to PO. Yet, increased amts. of PO do not exit perfused livers from phenobarbital-pretreated mice. Instead, the enhanced detoxification of I to PNP, PNPS, and PNPG likely results in the obsd.Except for chemicals metioned above, 311-45-5 and 9035-51-2 are also used. antagonism of I acute toxicity. .

Sex differences in the excretion of glucuronide conjugates: the role of intrarenal glucuronidation

Sex differences in the excretion of glucuronide conjugates: the role of intrarenal glucuronidation. Rush, Glenn F.; Newton, John F.; Hook, Jerry B. (Cent. Environ. Toxicol., Michigan State Univ., East Lansing, MI, USA). J. Pharmacol. Exp. Ther., 227(3), 658-62 (English) 1983. CODEN: JPETAB. ISSN: 0022-3565. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 1 Female rats administered p-nitrophenol (I) [100-02-7] (0.05 mmol/kg) excrete more p-nitrophenyl glucuronide (II) [10344-94-2] in the urine than males (35.9 vs. 14.1% of total urinary metabolites, resp.). In contrast, hepatic microsomes prepd. from male rats have higher UDP-glucuronyltransferase [9030-08-4] activity toward I than hepatic microsomes from females (6.49 vs. 3.20 nmol/min/mg of protein, resp.). Sex differences in II excretion may be due to sex differences in biliary excretion of glucuronide conjugate or extrahepatic conjugation of I. UDP-glucuronyltransferase activity in renal microsomes prepd. from male and female rats toward I was 0.21 and 0.91 nmol/min/mg of protein, resp. 57-27-2 and 90-15-3 are cas registry numbers of chemicals which are used as reagents here. Vmax Was greater in females than in males; Km was not sex linked. Similar in vitro sex differences were also obsd. with 1-naphthol [90-15-3] as the aglycon. In contrast, renal microsomes prepd. from male or female rats did not glucuronidate morphine [57-27-2]. Likewise, no sex differences in the excretion of morphine glucuronide [20290-09-9] were obsd. (16.4 vs. 23.9% of total urinary conjugates from males and females, resp.). During infusion of 2 mmol/min/kg of I, 897.9 nmol/min/kg of in vivo formed II was excreted in the urine of female rats; whereas 715.6 nmol/min/kg was excreted in males. Urinary excretion of II that was formed in the kidney was 198.9 and 76.0 nmol/min/kg in female and male rats, resp. Biliary excretion of II represented ~6% of the administered dose, with no different between the sexes. Renal UDP-glucuronyltransferase may contribute to the sex differences in II excretion. .