Reference

A comparison in rabbit isolated hearts of the dysrhythmogenic potential of amitriptyline, maprotiline and mianserin in relation to their ability to block noradrenaline uptake

A comparison in rabbit isolated hearts of the dysrhythmogenic potential of amitriptyline, maprotiline and mianserin in relation to their ability to block noradrenaline uptake. Harper, Barbara; Hughes, I. E. (Med. Sch., Univ. Leeds, Leeds, Engl.). Br. J. Pharmacol., 59(4), 651-60 (English) 1977. CODEN: BJPCBM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In isolated hearts of rabbits, perfusion with amitriptyline-HCl [549-18-8], maprotiline-HCl [10347-81-6] (4.8.mu.M), or mianserin-HCl [21535-47-7] (28.8.mu.M) reduced ventricular force but did not change heart rate; only amitriptyline reduced atrial force and lengthened the interval between peak atrial and peak ventricular tensions (A-V contraction interval). At higher concns. (amitryptyline 8, maprotiline 8, and mianserin 60.mu.M), all the agents produced dysrhythmias interfering with atrioventricular synchronization. In the presence of mianserin (4.8.mu.M), perfusion with (-)-noradrenaline bitartrate [51-40-1] (0.0059-5.9.mu.M) shortened the A-V contraction interval but did not produce dysrhythmias. In the presence of amitriptyline, maprotiline (4.8.mu.M), or mianserin (28.8.mu.M), noradrenaline perfusion results in the lengthening of the A-V contraction interval and dysrhythmias. 3H-labeled noradrenaline uptake in perfused rabbit hearts and mouse isolated atria or vasa deferentia was inhibited by the antidepressants to a similar extent. Predisposition to noradrenaline-induced dysrhythmias produced by the antidepressants was not related to blockade of noradrenaline uptake.

Effect of antidepressants on the absorption of serotonin by human thrombocytes

Effect of antidepressants on the absorption of serotonin by human thrombocytes. Oksenkrug, G.In this study， 5118-29-6 and 14368-24-2 are also used. F. (Leningr. Nauchno-Issled. Psikhonevrol. Inst. im. Bekhtereva, Leningrad, USSR). Farmakol. Toksikol. (Moscow), 40(2), 146-8 (Russian) 1977. CODEN: FATOAO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) All 15 antidepressants tested decreased the absorption of serotonin [50-67-9] by human thrombocytes in vitro. In decreasing order of effectiveness they were: chlorimipramine [303-49-1], imipramine [50-49-7], prothiaden [113-53-1], quipazine [4774-24-7], amitriptyline [50-48-6], trausabun [5118-29-6], imipramine N-oxide [6829-98-7], nortriptyline [72-69-5], demethylimipramine [50-47-5], trimipramine [739-71-9], noveril [315-80-0], ludiomil [10347-81-6], iprindole [5560-72-5], tacitin [10085-81-1], and origen [14368-24-2]. .