Detail of "1035-77-4"

Reference

Improved delivery through biological membranes

Improved delivery through biological membranes.Some chemicals with cas registry numbers like 1453-82-3 are also used. XXII. Synthesis and distribution of brain-selective estrogen delivery systems. Bodor, Nicholas; McCornack, Jill; Brewster, Marcus E. (Cent. Drug Des. Delivery, Univ. Florida, Gainesville, FL 32610, USA). Int. J. Pharm., 35(1-2), 47-59 (English) 1987. CODEN: IJPHDE. ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 2, 32 1,4-Dihydrotrigonelline derivs. (I [103562-82-9], II [106146-67-2] and III [106146-66-1]) of the estrogens, b-estradiol (E2) [50-28-2], estrone (E1) [53-16-7] and estradiol-3-methyl ether (3MeE2) [1035-77-4] were synthesized as potential brain-selective delivery forms for these steroids. Initial in vivo screening showed that the estradiol chem. delivery system (I) was most appropriate for further in vivo study. Accordingly, when I was systemically administered to rats, sustained levels of the oxidized trigonelline ester delivery system (E2Q+) were found in the brain while peripheral levels of E2Q+ rapidly fell. In addn., radioimmunoassay and spectroscopic methods detected E2 in the brain after administeration of I. The undetectable levels of E2 in the blood suggest that the E2 found in the central nervous system was derived from centrally delivered E2Q+ and not from peripheral sources. .

Thermoanalytical and IR spectroscopic studies on several crystal forms of estradiol and androstane type drugs

Thermoanalytical and IR spectroscopic studies on several crystal forms of estradiol and androstane type drugs.Some chemicals with cas registry numbers like 6045-52-9 and 302-76-1 are also used. Part 1. Kuhnert-Brandstaetter, M.; Winkler, H. (Inst. Pharmakog., Univ. Innsbruck, Innsbruck, Austria). Sci. Pharm., 44(3), 177-90 (German) 1976. CODEN: SCPHA4. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 75 Polymorphism and pseudoplymorphism in .alpha.-estradiol [57-91-0], .beta.-estradiol (I) [50-28-2], methylestradiol [302-76-1], estradiol Me ether [1035-77-4], and estradiol monopropionate [1323-33-7] were studied by thermomicroscopy, differential scanning calorimetry, and IR spectroscopy. I, methylestradiol and estradiol monopropionate formed very stable hydrates, and these compds. in the com. form exist as the hydrates. The affinity of these compds. for H2O was so great that they crystd. as the hydrates even from anhyd. org. solvents, with the atm. moisture being sufficient to cause conversion to the hydrates. Some new polymorphic modifications were also obsd. .