Reference

Method for treating renal disease using an ACE inhibitor and an angiotensin II antagonist

Method for treating renal disease using an ACE inhibitor and an angiotensin II antagonist. Remuzzi, Giuseppe; Eydelloth, Ronald S.Several substances are used for example 127060-75-7 and 103775-10-6 which are their cas registry numbers.; Owen, Roger A.; Shahinfar, Shahnaz (Merck and Co., Inc.; Laboratoires Merck Sharp & Dohme-Chibret Snc; Remuzzi, Giuseppe; Eydelloth, Ronald S.; Owen, Roger A.; Shahinfar, Shahnaz, USA). PCT Int. Appl. WO 9702032 A1 23 Jan 1997, 32 pp. DESIGNATED STATES: W: AL, AM, AU, AZ, BB, BG, BR, BY, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KG, KR, KZ, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TR, TT, UA, US, UZ, VN, AM, AZ, BY, KG, KZ; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K031-40. ICS: A61K031-495; A61K031-50; A61K031-675; A61K031-47; A61K031-41; A61K031-415; A61K031-505. APPLICATION: WO 1996-US10942 26 Jun 1996. PRIORITY: US 1995-770 30 Jun 1995; GB 1996-2854 13 Feb 1996. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 63 The present invention relates to a method of treating and/or preventing renal disease with the coadministration of an ACE inhibitor and an AII receptor antagonist. The present invention also relates to a method for protection of renal structure and/or renal function with the coadministration of an ACE inhibitor an an AII receptor antagonist. The combination is also useful in preventing renal injury and protecting glomerular structure. The effect of Lisinopril (ACE inhibitor) and Losartan (angiotensin II receptor antagonist) in animals with diabetic nephropathy is described. .