Detail of "103775-75-3"

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Synthesis of platinum-195m radiolabeled (-)-(R)-2-aminomethyl-pyrrolidine(1,1-cyclobutanedicarboxylato)-2-plati num(II) monohydrate using high performance liquid chromatography

Synthesis of platinum-195m radiolabeled (-)-(R)-2-aminomethyl-pyrrolidine(1,1-cyclobutanedicarboxylato)-2-plati num(II) monohydrate using high performance liquid chromatography. Kawai, K.; Takada, S.; Nakano, Y.; Ehrlich, W.; Maki, H.; Akaboshi, M. (Res. React. Inst., Kyoto Univ., Sennan 590, Japan). J. Radioanal. Nucl.In this article, certain chemicals are used. Some of their cas registry numbers are 141052-69-9 and 103775-75-3 Chem., 164(2), 123-30 (English) 1992. CODEN: JRNCDM. ISSN: 0236-5731. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 78 An exptl. method is described for the synthesis of 195mPt-labeled (-)-(R)-2-aminomethylpyrrolidine-(1,1-cyclobutanedicarboxylato)-2-plati num (II) (DWA2114R). An amt. of 10 mg of 95% enriched 194Pt was irradiated for 75 h in the hydraulic conveyer of the KUR Kyota University reductase at a thermal neutron flux of 8.1 ′ 1013 neutrons/cm2/s and the 195mPt-labeled DWA2214R was purified using HPLC. The chem. yield is >65%, its chem. purity is >99.2%, the radiochem. purity is nearly 100%, and the specific activity is 6.7 MBq/mg DWA2114R. .

The interactions of (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinum (II) monohydrate (DWA 2114R) and related compounds with deoxyribonucleic acid

The interactions of (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinum (II) monohydrate (DWA 2114R) and related compounds with deoxyribonucleic acid. Morikawa, Kazumi; Matsumoto, Tomoko; Matsuoka, Yukio; Koizumi, Kinya (Explor. Res. Lab., Chugai Pharm. Co., Ltd., Gotemba 412, Japan). Chem. Pharm. Bull., 40(1), 212-19 (English) 1992. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The interactions of a new antitumor platinum (Pt) complex, (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutane-dicarboxylato)platinu m(II) monohydrate (DWA2114R) and its related compds., cis-diamminedichloroplatinum(II) (CDDP), trans-diamminedichloroplatinum(II) (TDDP), (+)-(S)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinu m(II) monohydrate (DWA2114S), (R)-2-aminomethylpyrrolidinedichloroplatinum(II) (I), and cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) (CBDCA), with calf thymus DNA and DNA nucleosides were investigated by UV and CD spectrometry. The UV spectra of the DNAs treated with these Pt complexes exhibited both bathochromic shift and hyperchromicity, showing a binding of Pt to the heterocyclic groups of these DNA as well as an alteration in the secondary structure of DNA. The reaction rates of the Pt complexes with DNA, however, differed from one another, and the order was CDDP, TDDP, I ? DWA2114R, DWA2114S > CBDCA. The CD spectra of the DNAs treated with the Pt complexes, except TDDP, at a low Pt ratio (