Detail of "10379-14-3"

CAS Number:
10379-14-3
Name:
2H-1,4-Benzodiazepin-2-one,7-chloro-5-(1-cyclohexen-1-yl)-1,3-dihydro-1-methyl-
Molecular Structure:
Formula:
C16H17 Cl N2 O
Molecular Weight:
288.80
Synonyms:
7-Chloro-5-(cyclohexen-1-yl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one;7-Chloro-5-cyclohexenyl-1-methyl-2-oxo-2,3-dihydro-(1H)-1,4-benzodiazepine; CB4261; Musaril; Myolastan; Ro 06-6657; Tetrazepam
Density:
1.27g/cm³
Boiling Point:
502.1°Cat760mmHg
Flash Point:
257.5°C
Safety:
Moderately toxic by ingestion and intraperitoneal routes. A tranquilizer and muscle relaxant. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x. See also DIAZEPAM and KETONES. Details

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Pharmacokinetics and metabolite pattern of tetrazepam and chlordesmethyldiazepam: Pharmacokinetics and metabolite pattern of tetrazepam and chlordesmethyldiazepam. Staak, M.; Sticht, G.; Kaeferstein, H.; Norpoth, T. (Inst. Rechtsmed., Univ. Koeln, Cologne D-5000/30, Fed. Rep. Ger.). Beitr. Gerichtl. Med., 42, 75-9 (German) 1984. CODEN: BEGMA5. ISSN: 0067-5016. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) After oral tetrazepam (I) [10379-14-3] at 50 mg, max serum concns. of 390-720 ng/mL were obsd. in healthy men. The elimination half-life was 16.0 h. Only trace amts. of the I metabolite nortetrazepam [10379-11-0] were detected. After oral chlordesmethyldiazepam (II) [2894-67-9] at 3 mg, max. serum concns. of 25-31 ng/mL were obsd. The elimination half-life was 97.3 h. Only trace amts. of the II metabolite lorazepam [846-49-1] were detected in the serum samples. Lorazepam glucuronide [32781-79-6] was the major component of urinary excretion.

Biotransformation and pharmacokinetics of tetrazepam in man: Biotransformation and pharmacokinetics of tetrazepam in man. Baumgaertner, M. G.; Cautreels, W.; Langenbahn, H. (Med. Dep., Midy Arzneimittel G.m.b.H., Munich, Fed. Rep. Ger.). Arzneim.-Forsch., 34(6), 724-9 (English) 1984. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 63 The pharmacokinetics and the metab. of Musaril (tetrazepam)(I) [10379-14-3] were studied in 12 healthy volunteers. Tetrazepam was given orally as a single dose of 50 mg in tablet form (com. available formulation). Tetrazepam and nortetrazepam [10379-11-0] were measured in serum using a selective and sensitive HPLC method. Urinary metabolites were identified after acid hydrolysis and thin-layer chromatog. sepn. Tetrazepam was rapidly absorbed after oral administration with a lag-time of 0.45 h and reached a peak serum level of 0.57 mg/L at 1.92 h after administration. The drug was largely distributed in the organism with an apparent vol. of distribution of 225 L.In this article, certain chemicals are used. One of their cas registry numbers is 92558-23-1 Tetrazepam was eliminated with a half-life of 14.9 h and can be classified as a benzodiazepine with medium half-life value. This medium half-life is the result of the high hepatic clearance of the drug in spite of its large distribution vol. No sex-related differences were obsd. in the pharmacokinetic profiles of the drug. .