Detail of "104-14-3"

CAS Number:
104-14-3
Name:
Benzenemethanol, a-(aminomethyl)-4-hydroxy-
Superlist Name:
Octopamine
Molecular Structure:
Formula:
C8H11 N O2
Molecular Weight:
153.20
Synonyms:
Benzylalcohol, a-(aminomethyl)-p-hydroxy-(6CI,8CI); (RS)-Octopamine; (?à)-Octopamine; 1-(p-Hydroxyphenyl)-2-aminoethanol;2-Amino-1-(4-hydroxyphenyl)ethanol; 4-Hydroxyphenethanolamine;4-[2-Amino-1-hydroxyethyl]phenol; Analet; DL-Octopamine; ND 50; Norden;Norphen; Norsympathol; Norsympatol; Norsynephrine; Norton; Octopamine; Racemicoctopamine; Win 5512; dl-Octopamine; p-Hydroxyphenylethanolamine; p-Octopamine;a-(Aminomethyl)-p-hydroxybenzylalcohol; b-Hydroxy-b-(4-hydroxyphenyl)ethylamine
EINECS:
203-179-5
Density:
1.249g/cm³
Boiling Point:
360.7°Cat760mmHg
Flash Point:
172°C
Safety:
Poison by intravenous route. Moderately toxic by intraperitoneal and subcutaneous route. When heated to decomposition it emits toxic fumes of NO_x. Details

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Effects of triethyltin on brain octopamines and their metabolism in the rat: Effects of triethyltin on brain octopamines and their metabolism in the rat. Coulon, J. F.; Lacroix, P.; Linee, P.; David, J. C. (Fac. Sci., Univ. Angers, Angers 49000, Fr.). Eur. J. Pharmacol., 135(1), 53-60 (English) 1987. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effects of triethyltin given acutely on the cerebral level of p- [104-14-3] and m-octopamine [536-21-0] were studied in rats. These octopamines were reduced drastically in hypothalamus and brainstem, whereas noradrenaline [51-41-2] and dopamine [51-61-6] were only slightly decreased. No changes were obsd. in the activities of tyrosine hydroxylase [9036-22-0], dopamine b-hydroxylase [9013-38-1] or monoamine oxidase [9001-66-5]. However, the activity of arom. L-amino acid decarboxylase [9042-64-2] was reduced.In this experiment, several chemicals are used like 536-21-0 and 9013-38-1 The addn. of the inhibitor of dopa decarboxylase [9042-64-2], Ro 44602, caused a total inhibition of this enzyme activity. Possible use is discussed of the triethyltin-induced cerebral edema as a model for the study of the phenolamine changes related to cerebral edema processes. .

Comparative studies on adrenergic receptors in different rat blood vessels: Comparative studies on adrenergic receptors in different rat blood vessels. Altura, Burton M. (Downstate Med. Cent., State Univ. New York, Brooklyn, N. Y., USA). Microcirc., [Proc. World Congr.], 1st, Meeting Date 1975, Volume 1, 255-6. Edited by: Grayson, John; Zingg, Walter. Plenum: New York, N. Y. (English) 1976. CODEN: 35LGAF. DOCUMENT TYPE: Conference CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 13 Although the relative contractile responses (i.e., the intrinsic activites IA's) for epinephrine (I) [51-43-4] and norepinephrine (II) [51-41-2] were 100% on rat metarterioles (MT), precapillary sphincters (PS), and aortic strips (AS), the IA's for II on mesenteric arterioles and muscular venules were less than for I. The dose-response curves for dopamine [51-61-6], octopamine [104-14-3], and phenylephrine [59-42-7] did not always parallel those of I and II for different blood vessels. The apparent dissocn. const. of phentolamine [50-60-2] for the receptor-agonist complexes also differed with vessel type. In addn. tyramine [51-67-2] and amphetamine [300-62-9] failed to contract MT and PS.