Detail of "104-98-3"

Reference

Novel GABA analogs as hypotensive agents

Novel GABA analogs as hypotensive agents. Matheson, G. K.; Freed, Elisabeth; Tunnicliff, G. (Sch. 2937-53-3 and 56-12-2 are also occured in this study. Med., Indiana Univ., Evansville, IN 47722, USA). Neuropharmacology, 25(11), 1191-5 (English) 1986. CODEN: NEPHBW. ISSN: 0028-3908. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The actions of 4 analogs of GABA [56-12-2] on blood pressure and heart rate were measured in the cat after intracerebroventricular administration. These compds. were previously found to inhibit binding to GABA receptors of neuronal membranes from the central nervous system of the rat. Each of the drugs, together with GABA, produced an av. max. redn. in blood pressure of 27.63%. However, aminoethanethiosulfonic acid [2937-53-3] was the most potent (ED50 = 2.24 ′ 10-10 mol/kg) of the drugs, followed by 5-phenyl-2-pyrrole propionic acid [79720-70-0] urocanic acid [104-98-3], m-aminobenzoic acid [99-05-8] and GABA. None of the compds. produced a significiant effect on heart rate. The fact that these analogs mimicked the action of GABA on the cardiovascular system of the cat and that they were able to inhibit binding to GABA receptors, indicates that they may be GABA agonists. .

Urocanic acid

Urocanic acid. Nakayama, Kiyoshi; Araki, Kazumi; Shimojo, Setsuko (Kyowa Hakko Kogyo Co., Ltd., Japan). Japan. Kokai JP 52096793 13 Aug 1977 Showa, 6 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C12D013-06. APPLICATION: JP 76-11226 6 Feb 1976. DOCUMENT TYPE: Patent CA Section: 16 (Fermentations) Urocanic acid [104-98-3] is produced by a Brevibacterium mutant which lacks L-histidine assimilation and is resistant to analogs of histidine, purines, pyrimidines, tryptophan, or phenylalanine, and to aminoglycoside antibiotics. Thus, B. ammoniagenes FTGT-41 (FERM-P 3409) resistant to 2-thiazolealanine, 3-amino-1,2,4,-triazole, 2-fluoroadenine, 6-mercaptoguanine, and 5-methyltryptophan was cultured with shaking at 30.degree. for 72 h on a medium (pH 7.2) contg. glucose 12, inverted molasses 3, (NH4)2SO4 4, K2HPO4 0.1, KH2PO4 0.2,urea 0.2, CaCO3 3, and meat ext. 1% plus trace amts. of FeSO4, MnSO4, MgSO4, thiamine-HCl, biotin, .beta.-alanine, Ca pantothenate, and cysteine-HCl. Prodn. of urocanic acid was 5.5 mg/mL.