Reference

Protein C, an anticoagulant protein, is increased in healthy volunteers and surgical patients after treatment with stanozolol

Protein C, an anticoagulant protein, is increased in healthy volunteers and surgical patients after treatment with stanozolol. Kluft, C.; Bertina, R. M.; Preston, F. E.; Malia, R. G.; Blamey, S. L.Chemicals with cas numbers 9001-25-6 and 9001-28-9 also play role.; Lowe, G. D. O.; Forbes, C. D. (Gaubius Inst., TNO, Leiden 2313 AD, Neth.). Thromb. Res., 33(3), 297-304 (English) 1984. CODEN: THBRAA. ISSN: 0049-3848. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) After both oral and i.m. administration, the anabolic steroid stanozolol [10418-03-8] increased protein C antigen concns. in circulating blood. In healthy young volunteers who received stanozolol orally, 10 mg/day, the av. increase was 1.5-1.6 times the normal concns. after 3-6 wk' treatment and was accompanied by more moderate increases in the other vitamin K-dependent factors (blood coagulation factor II [9001-26-7], IX [9001-28-9], and X [9001-29-0] to 1.4, 1.4 and 1.2 times their normal concn., resp. However, there was no change in factor VII [9001-25-6]. In elderly surgical patients, i.m. injection (50 mg) one day prior to surgery induced a moderate increase within 24 h (to 1.11 times the pretreatment concn.) and also 7 days after operation (to 1.19 times), and reduced the postoperative fall in protein C. Stanozolol administration seems to be a promising pharmacol. method for increasing anticoagulation protein C levels in congenital and acquired deficiencies. .

Experimental study on the hemopoietic effect of adrenergic and cholinergic drugs

Experimental study on the hemopoietic effect of adrenergic and cholinergic drugs. Cao, Luxian; Cao, Chengping; Da, Wanming; Huang, Yongshi; Li, Pingsheng; Ye, Qingfang (Lanzhou Mil. Dist. Gen. Hosp., Lanzhou, Peop. Rep. China). Zhonghua Xueyexue Zazhi, 4(4), 232-3 (Chinese) 1983. CODEN: CHTCD7. ISSN: 0253-2727. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The splenic colony-forming units (CFUs) and spleen wt. 525-66-6 and 55869-99-3 are also in the experiment. were both significantly increased in mice after oral administration of propranolol [525-66-6] (10 mg/kg) and stanozolol [10418-03-8] (30 mg/kg), but not in mice following i.p. injection of anisodamine [55869-99-3] (5mg/kg) and galanthamine [357-70-0] (2 mg/kg). In another expt., oral administration of salbutamol [18559-94-9] (8 mg/kg) significantly increased the splenic CFUs but not spleen wt. Thus, b-adrenergic, but not cholinergic, blockers may effectively stimulate hemopoietic activity. .