Detail of "10420-89-0"

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CAS Number:
10420-89-0
Name:
(S)-(-)-1-(1-Naphthyl)ethylamine
Molecular Structure:
Formula:
C₁₂H₁₃N
Molecular Weight:
171.24
Synonyms:
1-Naphthalenemethanamine, alpha-methyl-, (alphaS)-;1-Naphthalenemethanamine, alpha-methyl-, (S)-(-)-;(S)-alpha-Methyl-1-naphthalenemethanamine;[(1S)-1-naphthalen-1-ylethyl]azanium;(1S)-1-naphthalen-1-ylethanamine;(S)-(-)-1-(1-naphthyl) ethylamine;(S)-(-)-1-(1-Naphtyl)Ethylamine;(S)-(-)-alpha-(1-naphthyl)ethylamine;(S)-1-(1-Naphthyl)ethylamine;
EINECS:
223-425-5
Density:
1.067
Boiling Point:
289.9 °C at 760 mmHg
Flash Point:
144.3 °C
Appearance:
Colorless to light yellow liqui
Hazard Symbols:
Risk Codes:
36/37/38
Safety:
26-36-37/39 Details

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Optical resolution of (+)-2-chlorobutanoic acid: Optical resolution of (+)-2-chlorobutanoic acid. Nohira, Hiroyuki; Kai, Mariko (Japan). Jpn. Kokai Tokkyo Koho JP 61227549 A2 9 Oct 1986 Showa, 3 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: C07C053-15. ICS: C07C051-42. ICA: C07B057-00.Several substances with their cas registry numbers 32653-32-0 and 10420-89-0 may be metioned in this study. APPLICATION: JP 85-66533 1 Apr 1985. DOCUMENT TYPE: Patent CA Section: 23 (Aliphatic Compounds) (±)-2-Chlorobutanoic acid (±)-(I) is optically resolved by salt formation with 1-(1-naphthyl)ethylamine (II), sepn. of (+)-I-II and (-)-I-II salts in solvents by fractional dissoln., and treatment of the sepd. salts with a base. .

Determination of the enantiomeric composition of ibuprofen in human plasma by high-performance liquid chromatography: Determination of the enantiomeric composition of ibuprofen in human plasma by high-performance liquid chromatography. Avgerinos, A.; Hutt, A. J. (Dep. Pharm., Brighton Polytech., Brighton BN2 4GJ, UK). J. Chromatogr., 415(1), 75-83 (English) 1987. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A normal-phase high-performance liq. chromatog. method, using a hexane-EtOH solvent system, for the detn. of the enantiomeric compn. of ibuprofen (I) [15687-27-1] in human plasma is described. 51146-56-6 and 10420-89-0 are cas registry numbers of chemicals which are used as reagents here. The method is based on the resoln. of the diastereoisomeric amides formed on reaction of the I enantiomers with S-1-(naphthen-1-yl)ethylamine [10420-89-0] using p-chlorophenoxyacetic acid as internal std. The enantiomeric compn. of I in human plasma following the repeated oral administration of the drug to 2 volunteers is reported. The plasma concns. of S-(+)-I [51146-56-6] were always greater than that of R-(-)-I [51146-57-7], the ratio of the areas under the enantiomer plasma concn.-time curves (S/R) being 1.8 and 1.6. .