Detail of "10504-35-5"

Reference

Ethanol-ascorbate interrelationship in acute and chronic alcoholism in the guinea pig

Ethanol-ascorbate interrelationship in acute and chronic alcoholism in the guinea pig. Yunice, Aniece A.; Hsu, Heng M.; Fahmy, Aly; Henry, Sherry (Veterans Adm. Med. Cent., Oklahoma City, OK 73190, USA). Proc. Soc. Exp. Biol. Med., 177(2), 262-71 (English) 1984. CODEN: PSEBAA. ISSN: 0037-9727. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effects of low (200 ppm) and high (2000 ppm) ascorbic acid (I) [10504-35-5] in a nutritionally adequate diet, on blood EtOH [64-17-5] levels were studied in permanently carotid-cannulated, EtOH-infused, unanesthetized guinea pigs. In the acute study, the postinfusion rate of EtOH decline in the blood of animals treated with I was significantly higher when compared with animals treated with fructose, and the rate in the 2 treated groups significantly higher than in untreated controls. In the chronic study, animals were infused with sublethal doses of EtOH (30% of the total caloric intake) for 8 wk. Blood EtOH levels monitored throughout this period showed, at 3 h postinfusion, a lower concn. in the group on a high I diet. Both exptl. groups receiving EtOH lost significantly more body wt. in the 2nd week of dieting; but, while the group on high I regained wt. steadily thereafter, the group on low I was still 50 g below the controls at the end of the expt. Liver, kidney, and adrenal I concns. were lower in the EtOH-treated groups compared to the controls. Examinatikon of the liver revealed more fatty metamorphosis or steatosis in the low I group, but there was no evidence of liver fibrosis or cirrhosis. These results demonstrate the feasibility of utilizing the guinea pig for the study of the biochem. and morphol. sequelae of alcoholism. They further support the contention that a diet which is nutritionally adequate may no longer be so in the presence of high EtOH intake, and supplemental vitamin C ingestion may afford protection against EtOH toxicity.

Effect of long-term ascorbic acid ingestion on the carcinogenicity of "rustproof" fluid in Wistar rats

Effect of long-term ascorbic acid ingestion on the carcinogenicity of "rustproof" fluid in Wistar rats. Wang, Da; Wang, Hengwen (Shanghai Inst. Cell. Biol., Acad. Sin., Shanghai, Peop. Rep. China). Huanjing Kexue Xuebao, 6(3), 364-7 (Chinese) 1986. CODEN: HKXUDL. ISSN: 0253-2468. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 59 Ingestion of rustproof fluid comprised of NaNO2, triethanolamine [102-71-6], and polyethylene glycol [25322-68-3] (corresponding to daily intake of 75 mg NaNO2) for 2 yr by 40 male Wistar rats induced 32.5% malignant tumors including 22.5% acinar adenocarcinoma of the pancreas; 30% hyperplasia and atypical hyperplasia of pancreatic acini was also detected. The control group receiving the same treatment together with daily intake of 150 mg ascorbic acid [10504-35-5] through drinking water for 2 yr had much less pancreatic hyperplasia and carcinoma (both 2.5% only). The agent causing pancreatic lesions in rats might be a new nitrosamine formed in vivo by ingredients of the ingested fluid and oral ascorbic acid ingestion could be a means of protecting the workers exposed to the fluid.