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CAS No.: | 1053239-39-6 |
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Name: | 2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine hydrochloride |
Article Data: | 5 |
Molecular Structure: | |
Formula: | C13H18ClNO |
Molecular Weight: | 239.745 |
Synonyms: | 2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylaMine hydrochloride; 1,6,7,8-Tetrahydro-2H-Indeno[5,4-B]Furan-8-Ethanamine Hydrochloride |
Density: | 1.058±0.06 g/cm3 (20oC 760 Torr) |
Melting Point: | 165-167℃ |
PSA: | 35.25000 |
LogP: | 3.50240 |
2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)acetonitrile
2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride
Conditions | Yield |
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With hydrogen; platinum(IV) chloride In methanol; chloroform at 30 - 40℃; under 2250.23 - 3750.38 Torr; for 2h; Solvent; Reagent/catalyst; | 97% |
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / ethanol / 2 h / Large scale 2: hydrogenchloride / water; methanol / 1 h / 45 °C / Large scale View Scheme |
2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride
Conditions | Yield |
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Stage #1: (2E)-2-(4,5-dibromo-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)ethanamine hydrochloride With sodium carbonate In water; toluene Stage #2: With hydrogen; sodium acetate; palladium 10% on activated carbon In methanol; toluene at 50℃; under 3310.08 Torr; Stage #3: With hydrogenchloride In isopropyl alcohol; toluene at 30℃; for 2h; pH=2; | 87% |
C13H15NO2
2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride
Conditions | Yield |
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Stage #1: C13H15NO2 With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran at 25 - 35℃; for 24 - 25h; Stage #2: With hydrogenchloride In water; ethyl acetate |
2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride
Conditions | Yield |
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With palladium 10% on activated carbon; hydrogen In methanol; water at 20℃; |
1,2,6,7-tetrahydro-8H-indeno[5,4-b]-furan-8-one
2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride
Conditions | Yield |
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Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran / 1 h / 25 °C / Large scale 1.2: 3.5 h / Large scale 2.1: sodium tetrahydroborate / ethanol / 2 h / Large scale 3.1: hydrogenchloride / water; methanol / 1 h / 45 °C / Large scale View Scheme |
2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride
Conditions | Yield |
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With hydrogenchloride In methanol; water at 45℃; for 1h; Large scale; | 4.1 kg |
2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride
propionic acid anhydride
Conditions | Yield |
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With sodium hydrogencarbonate In water at 5 - 10℃; for 1h; pH=5.5; | 86% |
2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride
propionyl chloride
Conditions | Yield |
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Stage #1: 2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride With sodium hydroxide In tetrahydrofuran at 5 - 10℃; for 0.5h; pH=13 - 13.5; Stage #2: propionyl chloride In tetrahydrofuran at 5℃; pH=5.5 - 6.0; | 75% |
With triethylamine In tetrahydrofuran at 10 - 35℃; for 2 - 3h; |
2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride
butyryl chloride
Conditions | Yield |
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67% | |
With sodium hydroxide In water | 67% |
2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride
(-)-O,O′-dibenzoyl-L-tartaric acid monohydrate
Conditions | Yield |
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Stage #1: 2‑(1,6,7,8‑tetrahydro‑2H‑indeno[5,4‑b]furan‑8‑yl)ethylamine hydrochloride With sodium hydroxide In dichloromethane; water Stage #2: (-)-O,O′-dibenzoyl-L-tartaric acid monohydrate In acetonitrile at 60℃; |