Detail of "105431-72-9"

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The effect of 3,3-dipyridylmethyl-1-phenyl-2-indolinone on the neuromuscular transmission in the rodent skeletal muscles

The effect of 3,3-dipyridylmethyl-1-phenyl-2-indolinone on the neuromuscular transmission in the rodent skeletal muscles. Tsai, M. C.; Su, J. L.; Chen, M. L.; Fan, S. 105431-72-9 is the cas registry number. This chemical is also mentioned in this article. Z.; Cheng, C. Y. (Coll. Med., Natl. Taiwan Univ., Taipei, Taiwan). Neuropharmacology, 31(1), 89-94 (English) 1992. CODEN: NEPHBW. ISSN: 0028-3908. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of a cognition enhancer, 3,3-dipyridylmethyl-1-phenyl-2-indolinone (DPMPI, I, 21.5-645 mM), on neuromuscular transmission were studied electrophysiol. on diaphragms of the mouse and rat and the soleus muscle of the rat. DPMPI increased both direct and indirect twitch tension of the mouse diaphragm. It also increased the frequency of miniature endplate potentials and the quantal of endplate potential. DPMPI (64.5 mM) affected neither the amplitude of the directly elicited action potential of the soleus muscle in the rat nor the magnitude of the resting membrane potential of the mouse diaphragm, although DPMPI (215 mM) decreased the amplitude of the compd. action potential of the phrenic nerve. Thus, DPMPI had several effects on neuromuscular transmission: it facilitated the transmitter-releasing process of the motor nerve terminal, decreased conduction in the phrenic nerve, and increased the directly elicited twitch tension. .

Linopirdine reduces stimulus intensity threshold for induction of long-term potentiation in the Schaffer collateral/CA1 pathway in rat hippocampal slices

Linopirdine reduces stimulus intensity threshold for induction of long-term potentiation in the Schaffer collateral/CA1 pathway in rat hippocampal slices. Lampe, Betty J.; Gaskill, Jacqui L.; Keim, Susan C.; Brown, Barry S. ( Preclinical Pharmacology, DuPont Merck Research Laboratories, P.O. Box 80400, Wilmington, DE 19880-0400, USA). Neuroscience Letters, 222(2), 135-137 (English) 1997 Elsevier. CODEN: NELED5. ISSN: 0304-3940. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Linopirdine, a putative cognition enhancing agent, increases neurotransmitter release and blocks M-current in rat brain. Its effects on long-term potentiation (LTP) in the Schaffer collateral/CA1 pathway were investigated using std. 105431-72-9 which is the cas registry number of some chemical is mentioned., extracellular recording techniques in the rat hippocampal slice prepn. When using a half maximal stimulus intensity for tetanic stimulation, a 30 min exposure to 3 or 10 mM linopirdine exerted no significant effect on excitatory postsynaptic potential (EPSP) slope, post-tetanic potentiation or LTP. In contrast, when a weak stimulus was employed, linopirdine enhanced the incidence and amplitude of LTP in a dose-dependent manner. These results indicate that linopirdine reduced stimulus intensity threshold for induction of LTP, an effect which may be mediated by its ability to enhance presynaptic glutamate release and cause CA1 membrane depolarization. .