Detail of "105637-50-1"

MSDS Download
CAS Number:
105637-50-1
Name:
1H-1,4-Diazepine,1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-, hydrochloride (1:1)
Molecular Structure:
Formula:
C₁₅H₁₈Cl₂N₂O₂S
Molecular Weight:
361.29
Synonyms:
1H-1,4-Diazepine,1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-, monohydrochloride (9CI);1-(5-Chloronaphthyl-1-sulfonyl)homopiperazine hydrochloride;ML 9;
Melting Point:
196-200 °C
Boiling Point:
508.8 °Cat760mmHg
Flash Point:
261.5 °C
Solubility:
ethanol: 10 mg/mL
Appearance:
crystalline solid

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The modulatory role of myosin light chain phosphorylation in human platelet activation: The modulatory role of myosin light chain phosphorylation in human platelet activation. Saitoh, Masahiro; Naka, Michiko; Hidaka, Hiroyoshi (Sch. Med., Mie Univ., Tsu 514, Japan). Biochem. Biophys. Res. Commun., 140(1), 280-7 (English) 1986. CODEN: BBRCA9. ISSN: 0006-291X. DOCUMENT TYPE: Journal CA Section: 13 (Mammalian Biochemistry) Myosin 20-kilodalton (K-Da) light chain phosphorylation in human platelets was catalyzed by myosin light chain kinase (MLCK) in the early phase during collagen activation. The effect of the selective inhibitor of MLCK, ML-9, on collagen-induced platelet activation was investigated. ML-9 delayed the time course of the myosin 20 K-Da light chain phosphorylation, sequentially leading to a delay in aggregation, secretion, and phosphorylation of the 40 K-Da peptide, in a dose-dependent fashion. 51845-53-5 and 105637-50-1 are just another two chemicals used in this study. The MLCK catalyzed phosphorylation of myosin 20 K-Da light chain may be an initial response, and if so, may influence the sequent reactions in the activation of platelets with collagen. .