Reference

Isolation of a mutant of Salmonella typhimurium strain TA 1535 with decreased levels of glutathione

Isolation of a mutant of Salmonella typhimurium strain TA 1535 with decreased levels of glutathione.Some chemicals with cas registry numbers like 759-73-9 and 70-18-8 are also used. Primary characterization and chemical mutagenesis studies. Kerklaan, P.; Bouter, S.; Mohn, G. (Dep. Radiat. Genet. Chem. Mutagenesis, State Univ. Leiden, Leiden 2333 AL, Neth.). Mutat. Res., 122(3-4), 257-66 (English) 1983. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) A mutant of S. typhimurium strain TA 1535 with decreased glutathione (GSH) [70-18-8] levels was isolated after treatment with UV and selection for N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) [4245-77-6] resistance; this GSH mutant also exhibited increased resistance to MNNG [70-25-7]. Estn. of the cellular GSH content showed that the GSH deriv. contained ~20% of the GSH levels found in TA 1535. In mutagenicity tests (hisG46?His+), the GSH strain required the presence of GSH or L-cysteine in the medium for an optimal phenotypic expression and(or) growth of spontaneous and induced His+ revertants, and may, therefore, be allelic to cys mutants of Salmonella. The mutagenic activity of MNNG, ENNG, and 1,2-dibromoethane (DBE) [106-93-4], but not N-ethylnitrosourea (ENU) [759-73-9], was strongly reduced in TA 1535/GSH; pretreatment of the strain with GSH restored the mutagenicity of the 1st 3 chem. to levels normally found in TA 1535. Thus, MNNG, ENNG, and DBE, but not ENU, can be activated via reaction with GSH to species of higher reactivity and mutagenicity. The GSH strain can be used to study more systematically the role of GSH in the bioactivation and -deactivation of xenobiotics to mutagenic factors. .

Effect of soil fumigation on the content of some macronutrients and trace elements (magnesium, calcium, potassium, phosphorus, sodium, zinc, manganese, iron, and copper) in tobacco leaves

Effect of soil fumigation on the content of some macronutrients and trace elements (magnesium, calcium, potassium, phosphorus, sodium, zinc, manganese, iron, and copper) in tobacco leaves. Basile, Martino (Ist. Nematol. Agrar., CNR, Bari, Italy). Inf. Fitopatol., 33(10), 51-3 (Italian) 1983. CODEN: INFTAP. ISSN: 0020-0735. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 11 In leaves of tobacco (Erzegovina var.) fumigation with DD [8003-19-8], Di Trapex [8066-01-1], Telone [542-75-6], EDB [106-93-4], Vapam [137-42-8] resulted in a slight increase in the concn. of P and decrease in the concn. of Mn. The Mg, Ca, K, Na, Zn, Fe, and Cu were not significantly altered by the fumigation.Except for chemicals metioned above, 7723-14-0 and 8066-01-1 are also used. .