Detail of "106477-83-2"
- CAS Number:
- 106477-83-2
- Name:
Pancreastatin (swine) (9CI)
- Formula:
- C214H330N68O76S
- Synonyms:
- Pancreastatin(pig);Glycinamide,glycyl-L-tryptophyl-L-prolyl-L-glutaminyl-L-alanyl-L-prolyl-L-alanyl-L-methionyl-L-a-aspartylglycyl-L-alanylglycyl-L-lysyl-L-threonylglycyl-L-alanyl-L-a-glutamyl-L-a-glutamyl-L-alanyl-L-glutaminyl-L-prolyl-L-prolyl-L-a-glutamylglycyl-L-lysylglycyl-L-alanyl-L-arginyl-L-a-glutamyl-L-histidyl-L-seryl-L-arginyl-L-glutaminyl-L-a-glutamyl-L-a-glutamyl-L-a-glutamyl-L-a-glutamyl-L-a-glutamyl-L-threonyl-L-alanylglycyl-L-alanyl-L-prolyl-L-glutaminylglycyl-L-leucyl-L-phenylalanyl-L-arginyl-;Pig pancreastatin;Porcine pancreastatin;Porcine pancreastatin(1-49);
Pancreastatin (swine) (9CI)
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Reference
- Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion
- Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion. Tatemoto, Kazuhiko; Efendic, Saud; Mutt, Viktor; Makk, George; Feistner, Gottfried J.; Barchas, Jack D. (Sch. Med., Stanford Univ., Stanford, CA 94305, USA). Nature (London), 324(6096), 476-8 (English) 1986. CODEN: NATUAS. ISSN: 0028-0836. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) A 49-residue peptide which strongly inhibits glucose-induced insulin release from isolated pancreas was isolated and characterized from porcine pancreas and was named pancreastatin (pig) [106477-83-2]. The complete amino acid sequence was detd. The synthetic fragments pancreastatin-(14-49) (pig) [106494-00-2] and pancreastatin-(33-49) (pig) [106507-61-3] also decreased glucose-induced insulin [9004-10-8] release to about the same extent as pancreastatin itself. Pancreastatin may be important in the regulation of insulin secretion and in the pathogenesis and treatment of diabetes mellitus.