Reference

Pharmaceutical and cosmetic microspheres manufactured with aliphatic fatty alcohols and acids

Pharmaceutical and cosmetic microspheres manufactured with aliphatic fatty alcohols and acids. Rolland, Alain (Centre International de Recherches Dermatologiques (CIRD), Fr.). Eur. Pat. Appl. EP 463962 A1 2 Jan 1992, 8 pp. 106685-40-9 and 112-72-1 are cas registry numbers. These chemicals are also mentioned in this article. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, NL, SE. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: A61K009-16. ICS: A61K009-50; A61K007-00. APPLICATION: EP 91-401723 26 Jun 1991. PRIORITY: FR 90-8014 26 Jun 1990. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 62 Pharmaceutical or cosmetic microspheres comprise C8-16 aliph. alcs., C8-15 aliph. acids and esters thereof or their mixts. A soln. of N-(2-hydroxyethoxyethyl)eicosatriynamide and tridecanol in EtOH was added to water, with stirring, to obtain microspheres which were sepd. and dried. .

Control of epidermal differentiation by a retinoid analog unable to bind to cytosolic retinoic acid-binding proteins (CRABP)

Control of epidermal differentiation by a retinoid analog unable to bind to cytosolic retinoic acid-binding proteins (CRABP). Asselineau, Daniel; Cavey, Marie Therese; Shroot, Braham; Darmon, Michel (Cent. Int. Rech. Dermatol. Galderma, Valbonne F-06565, Fr.). J. Invest. Dermatol.There are some reagents with their cas registry numbers 302-79-4 and 106685-40-9 are used in this study., 98(2), 128-34 (English) 1992. CODEN: JIDEAE. ISSN: 0022-202X. DOCUMENT TYPE: Journal CA Section: 13 (Mammalian Biochemistry) Section cross-reference(s): 1 The role played by cytosolic retinoic acid-binding proteins (CRABP) in the control of differentiation and morphogenesis by retinoids remains unclear, which contrasts with the presence of these binding proteins in tissues known to be targets for retinoic acid effects. Human epidermis represents a good system to address this question because 1) the effect of retinoids on keratinocyte differentiation is well documented; 2) epidermis contains CRABP, and the amt. of these proteins is modulated both by keratinization and retinoids; 3) the architecture of epidermis obtained in vitro by growing adult human keratinocytes on a dermal substrate can be modulated by retinoids added to the culture medium in a dose-dependent manner; and 4) most markers of epidermal differentiation are also modulated by retinoids in a dose-dependent manner. In this study, the authors compared, in dose-response expts., the biol. activities of retinoic acid and CD271, a substance unable to bind to CRABP, but able to bind to nuclear retinoic acid receptors (RAR). Retinoic acid and CD271 exert similar controls on epidermal morphogenesis and keratinocyte differentiation, as shown by the inhibition of the synthesis of suprabasal keratins, filaggrin, and transglutaminase. Therefore, the authors exclude a qual. role for CRABP in the control exerted by retinoids on the differentiation and morphogenesis of cultured human keratinocytes. Instead of being involved in the pathway via which retinoids control epidermal gene expression, CRABP might regulate the amt. of intracellular-active retinoic acid and thus control quant. the intensity of biol. effects. .