Detail of "1068-21-9"

Reference

Amidophosphate reaction products useful as flame-resistant agents

Amidophosphate reaction products useful as flame-resistant agents. Nachbur, Hermann; Rohringer, Peter (Ciba-Geigy A.-G., Switz.). Ger. Offen. DE 2620643 25 Nov 1976, 60 pp.Chemical with cas number 61596-17-6 also plays role. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07F009-24. PRIORITY: CH 75-6264 15 May 1975. DOCUMENT TYPE: Patent CA Section: 39 (Textiles) Section cross-reference(s): 23 Reaction products (I) of amidophosphates (RO)2P(O)NH2 (R = Me, Et; or RR = CH2CMe2CH2) with HCHO, contg. .gtoreq.2 amidophosphate groups, and etherified I are permanent fireproofing agents for cellulosic textiles. For example, condensation of 1 mol (EtO)2P(O)NH2 [1068-21-9] with 0.5 mol aq. HCHO at 20.degree. and evapn. of H2O at 60.degree. in vacuo gave a colorless, semisolid product (II) contg. [(EtO)2P(O)NH]2CH2 [61596-23-4]. Padding cotton fabric (150 g/m2) with an aq. bath (pH 5.6) contg. II 160, methylolated melamine 150, p-C9H19C6H4(OCH2CH2)9OH 2, HOCH2CMe2NH2.HCl 40, and 30% hexamethylolmelamine pentamethyl ether-stearic alkanolamide condensate 20 g/L, followed by heating at 80-160.degree., gave material having 0 s burning time and 10.5 cm tearing length (DIN 53906, vertical test) after one wasah and 0 s and 13.5 cm, resp., after 40 washes; hand was only slightly stiffer (1 vs. 0) than that of untreated fabric. .

A new synthesis of phosphoramidates: inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase

A new synthesis of phosphoramidates: inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase. Adams, Luke A.; Cox, Russell J.; Gibson, Jennifer S.; Mayo-Martin, M. Belen; Walter, Magnus; Whittingham, William (School of Chemistry, University of Bristol, Bristol BS8 1TS, UK). Chemical Communications (Cambridge, United Kingdom), (18), 2004-2005 (English) 2002 Royal Society of Chemistry. CODEN: CHCOFS. ISSN: 1359-7345. DOCUMENT TYPE: Journal CA Section: 29 (Organometallic and Organometalloidal Compounds) Section cross-reference(s): 7, 10, 22 A new, mild and high yielding synthesis of phosphoramidates (EtO)2PONHCOR is described: potassium salts of carboxylic acids RCO2K are treated with ethylchloroformate and the resulting activated anhydride-carbonates are then treated with LiNHP(O)(OEt)2 in situ. This methodol. is esp. suited to acid sensitive systems featuring BOC, tBu or acetal protecting groups.In this experiment, several chemicals are used like 1068-21-9 4-Aspartylphosphoramide (2S)-(HO)2PONHCOCH2CHNH2CO2H (4) was prepd. from (2S)-MeO2CH2CHN(BOC)2CO2tBu and has shown high activity in inhibition of the title enzyme (ASA-DH). Mol. modeling studies support the obsd. lack of a covalent binding of 4 to the active site of ASA-DH. .