CAS No.1068-57-1,Acethydrazide Suppliers

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Basic Information

Molecular Structure:
CAS No.:	1068-57-1
Name:	Acethydrazide
Article Data:	108

Formula:	C₂H₆N₂O
Molecular Weight:	74.0824
Synonyms:	Acetic hydrazide;Acetohydrazide;Acetohydrazine;Acetyl hydrazide;Acetylhydrazine;ENT-61241;Ethanehydrazonic acid;Hydrazine, acetyl-;Monoacetylhydrazine;NSC 2271;NSC 53155;Acetic acid, hydrazide;
EINECS:	213-948-7
Density:	1.041 g/cm³
Melting Point:	58-68 °C(lit.)
Boiling Point:	246 °C at 760 mmHg
Flash Point:	102.6 °C
Solubility:	soluble in water
Appearance:	white solid
Hazard Symbols:	Xn
Risk Codes:	22-36/38
Safety:	26-36
PSA:	55.12000
LogP:	0.08740

Synthetic route

: 108-24-7
acetic anhydride

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With pyridine; aluminum oxide; hydrazine at 102 - 104℃; for 1h; microwave irradiation;	100%

: 141-78-6
ethyl acetate

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate at 85℃; for 0.00277778h;	99%
With hydrazine hydrate	98%
With hydrazine hydrate In ethanol; ethyl acetate for 4h; Reflux;	98%

: 79-20-9
acetic acid methyl ester

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate at 40 - 75℃; for 4h; Temperature; Green chemistry; Large scale;	98%
With hydrazine hydrate In ethanol Heating;
With hydrazine hydrate Reflux;

: acetamido azide

: 5244-34-8
2,2'-ethane-1,2-diylbissulfanyl-bis-ethanol

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrogen In ethanol	98%
With hydrogen In ethanol	98%

: 64-19-7
acetic acid

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate for 0.0222222h; Microwave irradiation;	86%
With hydrazine hydrate Microwave irradiation;
Stage #1: acetic acid With sulfuric acid In methanol at 20℃; for 4h; Reflux; Stage #2: With hydrazine hydrate In methanol at 75℃; for 0.5h;

: 16067-88-2
N-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-acetamide

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With water; hydrazine In ethanol for 0.25h; Ambient temperature;	75%

: 603-69-0
ethyl 2-acetylacetoacetate

A: 35691-93-1
3,5-Dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester

B: 141-97-9
ethyl acetoacetate

C: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine In chloroform-d1 at 20℃;	A 32% B 68 % Spectr. C 68%
With hydrazine In chloroform-d1 at 20℃;	A 32% B 68% C 68 % Spectr.
With hydrazine In acetone at -20℃;	A 85 % Spectr. B 15% C 15%

...Expand

: 919-19-7
diethyl acetylphosphonate

: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 12h;	55%
With hydrazine In ethanol for 12h; Product distribution; Mechanism; reaction with other subst. hydrazines;	55%

: 896109-94-7
ethyl 4-(1-adamantyl)-3-oxo-2-(1-oxoethyl)butanoate

A: 3-(1-adamantylmethyl)-1H-pyrazol-5-one

B: 1068-57-1
acetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 4h; Reflux;	A 39% B n/a

: 896109-94-7
ethyl 4-(1-adamantyl)-3-oxo-2-(1-oxoethyl)butanoate

: 100-63-0
phenylhydrazine

A: 33566-14-2
4-adamantan-1-yl-3-oxobutyric acid ethyl ester

B: 1068-57-1
acetic acid hydrazide

C: 33566-15-3
3-(1-adamantylmethyl)-1-phenyl-1H-pyrazol-5-one

Conditions

Conditions	Yield
at 70℃; for 2h;	A n/a B n/a C 27%

...Expand

Raw Materials

815-68-9

569-37-9

127-09-3

60-29-7

39806-38-7

108-24-7

2208-07-3

79-20-9

Downstream Products

64-19-7

Total:161 Page 1 of 5 1 2 3 4 5 Next>>

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The Acetyl hydrazide, with the CAS registry number 1068-57-1, is also known as 1-Methylformylhydrazine. Its molecular formula is C₂H₆N₂O and classification codes are Carcinogens; Mutation data; Noxae. Moreover, it has the systematic name acetohydrazide and the product categories Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes; Pesticide Intermediates; Other Pesticides; Pesticide Intermediates; Herbicide Intermediates. However, this chemical should be kept cool and dry, away from oxides. What's more, it's metabolite of isoniazid in animals and humans.

Other characteristics of the Acetyl hydrazide can be summarised as followings: (1)ACD/LogP: -1.64; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.64; (4)ACD/LogD (pH 7.4): -1.64; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 3.05; (8)ACD/KOC (pH 7.4): 3.06; (9)#H bond acceptors: 3; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 23.55 Å²; (13)Index of Refraction: 1.432; (14)Molar Refractivity: 18.47 cm³; (15)Molar Volume: 71.1 cm³; (16)Polarizability: 7.32×10^-24cm³; (17)Surface Tension: 35.5 dyne/cm; (18)Density: 1.041 g/cm³; (19)Flash Point: 102.6 °C; (20)Enthalpy of Vaporization: 48.31 kJ/mol; (21)Boiling Point: 246 °C at 760 mmHg; (22)Vapour Pressure: 0.0279 mmHg at 25°C.

Production method of the Acetyl hydrazide: It could be obtained by the ethyl acetate and hydrazine hydrate in the presence of Al₂O₃. The reaction equation is as following: CH₃COOC₂H₅ + NH₂N₂.H₂O→CH₃CONHNH₂ + C₂H₅OH

Uses of the Acetyl hydrazide: It's important intermediates in organic synthesis, such as pyrazine ketones intermediates in pesticides, benzene and metribuzin intermediates in herbicide. It's mainly used for synthesis of nitric furosemide Long (nifuratrone) in medicine.

When you are using this chemical, please be cautious about it as the following: This chemical is harmful if swallowed. It's also irritating to eyes and skin.You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: O=C(NN)C
2.InChI: InChI=1/C2H6N2O/c1-2(5)4-3/h3H2,1H3,(H,4,5)
3.InChIKey: OFLXLNCGODUUOT-UHFFFAOYAS

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	42200ug/kg (42.2mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
mouse	LD50	intraperitoneal	153mg/kg (153mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 122, Pg. 110, 1958.
rabbit	LDLo	subcutaneous	116mg/kg (116mg/kg)	ENDOCRINE: HYPOGLYCEMIA	Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 87, 1927.