Reference

The Effect of Different Stages of Neuromuscular Block on the Bispectral Index and the Bispectral Index-XP Under Remifentanil/Propofol Anesthesia

The Effect of Different Stages of Neuromuscular Block on the Bispectral Index and the Bispectral Index-XP Under Remifentanil/Propofol Anesthesia. Dahaba, Ashraf A.; Mattweber, Markus; Fuchs, Andreas; Zenz, Wilhelm; Rehak, Peter H.; List, Werner F.; Metzler, Helfried ( Department of Anaesthesiology and Intensive Care Medicine, Karl-Franzens University, Graz, Austria). Anesthesia & Analgesia (Hagerstown, MD, United States), 99(3), 781-787 (English) 2004 Lippincott Williams & Wilkins. CODEN: AACRAT. ISSN: 0003-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Facial electromyog. activity and neuromuscular block could influence bispectral index (BIS) depth of anesthesia monitoring. In this study we examd., in 30 patients undergoing general surgical procedures, the effect of different stages of neuromuscular block on BIS monitoring and compared the conventional A-2000 BIS (BIS3.4) with the new BIS-XP (BISXP). At deep surgical anesthesia BIS3.4 of approx. 40, under a propofol 3.61 mg/mL target-controlled infusion and a 0.15-0.3 mg×kg-1×min-1 remifentanil infusion, mivacurium 0.15 mg/kg was administered. The onset of neuromuscular block triggered a brief transient odd divergence in response that manifested as a BIS3.4 increase from 43 ±4 to 49±7 (P = 0.007) and a BISXP decline from 41 ±3 to 35 ±3 (P = 0.003) at 1 ±0.2 min. Then, 2.There are some commonly used reagents with their cas registry numbers 106861-44-3 and 2078-54-8 in this article.5 ±1 min after mivacurium administration, both monitors returned to baseline values of 43 ±5 and 40 ± 4, resp. After that, BIS3.4 and BISXP did not significantly change during complete neuromuscular block or during various levels of neuromuscular recovery. At all phases, BISXP was significantly lower than BIS3.4. Our study indicated that the BIS3.4/BISXP bias and the wide limits of agreement do not allow values given by the two monitors to be used interchangeably. .

Dose-response and minimum time to satisfactory intubation conditions after mivacurium in children

Dose-response and minimum time to satisfactory intubation conditions after mivacurium in children. McCluskey, A.; Meakin, G. (Royal Manchester Children's Hospital, University Department Anaesthesia, Pendlebury/Manchester M27 4HA, UK). Anaesthesia, 51(5), 438-441 (English) 1996 Saunders. CODEN: ANASAB. ISSN: 0003-2409. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) We assessed neuromuscular blocking effects and tracheal intubation conditions following mivacurium in 121 anesthetized children aged 1-10 yr. The study was conducted in three parts. Parts 1 and 2 were undertaken during thiopentone-alfentanil-nitrous oxide anesthesia; neuromuscular blockade was evaluated by recording the force of contraction of the adductor pollices in response to train-of-four stimulation at 0.1 Hz. In part 1 the potency of mivacurium was detd. in 15 children using a single dose-response technique; in part 2 onset and recovery times were detd. in six children following a dose of mivacurium 0.2 mg.kg-1. In part 3 of the study, clin. intubation conditions were assessed in two groups of 50 children whose tracheas were intubated 60 or 90s after injection of mivacurium 0.2 mg.kg-1 during thiopentone-nitrous oxide anesthesia. The ED50 and ED95 of mivacurium were 54 and 105 mg.kg-1 resp. The times to 90% and 100% depression of control twitch were 1.3 (0.3) and 1.9 (0.5) min; times to 5%, 25%, 75% and 90% recovery were 6.4 (1.0), 8.4 (1.1), 12.5 (1.1) and 14.4 (1.9) min, resp. Intubation conditions were rated satisfactory in 33/50 children (0. There are some commonly used reagents like 106861-44-3 in this article.66, 95% confidence interval 0.51-0.79) at 60 s and in 49/50 children (0.98, 95% confidence interval 0.89-1.0) at 90 s (p = 0.0001). Intubation conditions 90 s after mivacurium 0.2 mg.kg-1 were significantly better than those obtained in 10 patients given anesthetic drugs alone (p = 0.002). .