Reference

Indirect atomic absorption analysis of ethambutol

Indirect atomic absorption analysis of ethambutol. Kovatsis, A. V.; Tsougas, M. A. (Dep. Leg. Med. Toxicol., Univ. Thessaloniki, Salonika, Greece). Arzneim.-Forsch., 28(2), 248-50 (English) 1978. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Ethambutol di-HCl [[EtCH(CH2OH)NH]2(CH2)2.2HCl](I) [1070-11-7] was detd. by at. absorption spectroscopy by extg. the complex formed between the free base of the drug with Cu ions in the presence of NaOH. The prefereed extn. solvent was MeEt ketone. The absorbance of ethambutol-Cu complex was linear ￡400 mg of I/mL. The absorbance of the sample decreased after 24 h. Precision of this method was higher than that of a colorimetric method.

Sensitive assay procedure for ethambutol hydrochloride via charge transfer complex formation

Sensitive assay procedure for ethambutol hydrochloride via charge transfer complex formation. Tan, Henry S. I.; Gerlach, Eric D.; Dimattio, Anthony S. (Coll. Pharm., Univ. Cincinnati, Cincinnati, Ohio, USA). J. Pharm. Sci., 66(6), 766-9 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) The charge transfer complex formation between ethambutol-HCl [1070-11-7] and I was investigated and utilized as the basis for a sensitive spectrophotometric procedure for ethambutol and its dosage forms. The solns. exhibited blue-shifted I bands at 293 and 360 nm. A Job's plot of corrected absorbance against the mole ratio of ethambutol to I indicated a 1:2 drug-I ratio. At 293 nm, the absorbance was linear (r = 0.9998) over the 0.25-15-.mu.g/mL concn. range, but the concn. range for best accuracy is 1.6-5.8 .mu.g/mL. The method can be applied successfully to the anal. of com. available ethambutol tablets.