CAS No.107007-99-8,Granisetron hydrochloride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	107007-99-8
Name:	Granisetron hydrochloride
Article Data:	3

Formula:	C₁₈H₂₅ClN₄O
Molecular Weight:	348.876
Synonyms:	1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, monohydrochloride(9CI);BRL 43694A;Kytril;1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, hydrochloride(1:1);1H-Indazole-3-carboxamide,1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, monohydrochloride, endo-;
EINECS:	634-603-0
Density:	1.33g/cm3
Melting Point:	290-292 °C
Boiling Point:	532 °C at 760 mmHg
Flash Point:	275.6 °C
Appearance:	white to off-white crystalline solid
Hazard Symbols:	Xn,Xi
Risk Codes:	22-62-37/38-36/37/38-36
Safety:	26-36-37
PSA:	50.16000
LogP:	3.44920

Synthetic route

: 109889-09-0, 124998-65-8
granisetron

: 107007-99-8
granisetron hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol	77%
With hydrogenchloride In water; toluene at 50 - 60℃;

: 76272-41-8, 141650-55-7, 76272-56-5
endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine

: 106649-02-9
1-methylindazole-3-carboxylic acid chloride

: 107007-99-8
granisetron hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; triethylamine In dichloromethane

: 107007-99-8
granisetron hydrochloride

: 109889-09-0, 124998-65-8
granisetron

Conditions

Conditions	Yield
With ammonia; water for 0.5h; Product distribution / selectivity;

Raw Materials

Downstream Products

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Chemistry

IUPAC Name: 1-Methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide hydrochloride
Empirical Formula: C₁₈H₂₅ClN₄O
Molecular Weight: 348.8703
Flash Point: 275.6 °C
Enthalpy of Vaporization: 80.77 kJ/mol
Boiling Point: 532 °C at 760 mmHg
Vapour Pressure: 2.12E-11 mmHg at 25 °C
Appearance: White to Off-White Crystalline Solid
Melting Point: 290-292 °C
storage temp.: Room temp
Classification Code of Granisetron hydrochloride (CAS NO.107007-99-8): Anti-emetic; Drug / Therapeutic Agent; Mutation data; Reproductive Effect
Product Categories: Pharmaceutical material and intermeidates; Active Pharmaceutical Ingredients; API; Heterocyclic Compounds; Intermediates & Fine Chemicals; Neurochemicals; Pharmaceuticals; Granisetron; Serotonin receptor; Serotonin

Uses

Granisetron hydrochloride (CAS NO.107007-99-8) is used as an antiemetic.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	3mg/kg (3mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING	Yakkyoku. Pharmacy. Vol. 43, Pg. 589, 1992.
dog	LDLo	oral	15mg/kg (15mg/kg)	BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 2697, 1995.
mouse	LD50	intravenous	17mg/kg (17mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990.
mouse	LD50	oral	350mg/kg (350mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.
rat	LD50	intravenous	14mg/kg (14mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990.
rat	LD50	oral	350mg/kg (350mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.

Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 22-62-37/38-36/37/38-36
R22:Harmful if swallowed.
R62:Risk of impaired fertility.
R37/38:Irritating to respiratory system and skin.
R36/37/38:Irritating to eyes, respiratory system and skin.
R36:Irritating to eyes.
Safety Statements: 26-36-37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37:Wear suitable gloves.
RTECS: NK7882200

Specification

Granisetron hydrochloride (CAS NO.107007-99-8), its Synonyms are 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide monohydrochloride ; Granisetron HCl ; Granisetron hydrochloride preservative free ; Kytril ; Kytril Injection ; endo-1-Methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide hydrochloride .