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CAS No.: | 107133-36-8 |
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Name: | Perindopril erbumine |
Article Data: | 35 |
Molecular Structure: | |
Formula: | C19H32N2O5.C4H11N |
Molecular Weight: | 441.612 |
Synonyms: | (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester, compound with tert-butylamine (1:1);Aceon (TN);S 9490-3;Perindopril erbumine/tert-butylamine;Perindopril erbumine [USAN];(2S,3aS,7aS)-1-{(2S)-2-[(1S)-1-(ethoxycarbonyl)butylamino]propanoyl}octahydro-1H-indole-2-carboxylic acid--2-methylpropan-2-amine (1/1);(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-ethoxycarbonylbutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid; 2-methylpropan-2-amine;S-9490-3;1H-Indole-2-carboxylic acid,1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)- butyl]amino]-1-oxopropyl]octahydro-,(2S,3aS,- 7aS)-,compd. with 2-methyl-2-propanamine (1:1);1H-Indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(R*)),2alpha,3abeta,7abeta))-, compd. with 2-methyl-2-propanamine (1:1);McN-A-2833-109;Perindopril erbumine (JAN/USAN);MCN-A 2833-109;Perindopril tert-butylamine;Perindopril; |
EINECS: | 600-798-6 |
Density: | 1.15 g/cm3 |
Melting Point: | 126-128 °C |
Boiling Point: | 537.4 °C at 760 mmHg |
Flash Point: | 278.8 °C |
Appearance: | white solid |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36 |
PSA: | 121.96000 |
LogP: | 3.71330 |
Conditions | Yield |
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In ethyl acetate Heating / reflux; | 95% |
In ethyl acetate Heating / reflux; | 95% |
In ethyl acetate Heating / reflux; | 95% |
Perindopril
perindopril tert-butylamine
Conditions | Yield |
---|---|
With tert-butylamine In ethyl acetate; acetonitrile Heating / reflux; | 95% |
With tert-butylamine In ethyl acetate at 20℃; for 1 - 1.5h; | 65% |
tert-butylamine
perindopril tert-butylamine
Conditions | Yield |
---|---|
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With tert-butylimino-tri(pyrrolidino)phosphorane In acetonitrile Stage #2: N-[1(S)-(ethoxycarbonyl)butyl]-L-alanine ester of acetonoxime In acetonitrile at 50℃; for 0.5h; Stage #3: tert-butylamine In dichloromethane at 0 - 10℃; for 0.5h; Product distribution / selectivity; | 90% |
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile Stage #2: N-[1(S)-(ethoxycarbonyl)butyl]-L-alanine ester of acetonoxime In acetonitrile at 40 - 45℃; Stage #3: tert-butylamine With hydrogenchloride In acetonitrile at 50 - 60℃; Product distribution / selectivity; | 90% |
Stage #1: benzylperindopril oxalate With hydrogen; 5%-palladium/activated carbon In ethanol at 30℃; under 3677.86 Torr; for 3h; Stage #2: tert-butylamine In ethanol Product distribution / selectivity; |
(2S,3aS,7aS)-perhydroindole-2-carboxylic acid
tert-butylamine
perindopril tert-butylamine
Conditions | Yield |
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Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With chloro-trimethyl-silane; triethylamine In dichloromethane at 20 - 25℃; for 2h; Stage #2: N-((S)-1-carbethoxybutyl)-L-alanyl chloride hydrochloride With triethylamine In dichloromethane at -15℃; for 2h; Stage #3: tert-butylamine In Isopropyl acetate Product distribution / selectivity; | 86% |
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With chloro-trimethyl-silane; triethylamine In dichloromethane at 20 - 25℃; for 2h; Stage #2: N-((S)-1-carbethoxybutyl)-L-alanyl chloride hydrochloride With triethylamine In dichloromethane at -15℃; for 2h; Stage #3: tert-butylamine In ethyl acetate Product distribution / selectivity; | 80% |
Stage #1: (2S,3aS,7aS)-perhydroindole-2-carboxylic acid With chloro-trimethyl-silane; triethylamine In dichloromethane at 20 - 25℃; for 2h; Stage #2: N-((S)-1-carbethoxybutyl)-L-alanyl chloride hydrochloride With triethylamine In dichloromethane at -15℃; for 2h; Stage #3: tert-butylamine In DMF (N,N-dimethyl-formamide) Product distribution / selectivity; | 78% |
Conditions | Yield |
---|---|
With hydrogenchloride; tert-butylamine; triethylamine In dichloromethane; water; acetonitrile | A 81% B n/a |
C12H23NO2Si
N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine
tert-butylamine
perindopril tert-butylamine
Conditions | Yield |
---|---|
Stage #1: N-<1(S)-(ethoxycarbonyl)butyl>-L-alanine With 1H-imidazole; thionyl chloride In dichloromethane at -10℃; for 2h; Stage #2: C12H23NO2Si In dichloromethane at -10 - 25℃; for 21h; Stage #3: tert-butylamine In acetonitrile Heating / reflux; | 61% |
Conditions | Yield |
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With hydrogen; palladium on activated charcoal In ethyl acetate under 2068.65 Torr; for 8h; |
Conditions | Yield |
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In dichloromethane Product distribution / selectivity; | |
In water Product distribution / selectivity; |
Conditions | Yield |
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In water at 20℃; for 1h; Product distribution / selectivity; |
Conditions | Yield |
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With hydrogen; 5%-palladium/activated carbon In ethanol at 30℃; under 3677.86 Torr; for 3h; Product distribution / selectivity; |
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The Molecular Structure of Perindopril erbumine (CAS NO.107133-36-8):
Empirical Formula: C19H32N2O5
Molecular Weight: 368.4678
Nominal Mass: 368 Da
Average Mass: 368.4678 Da
Monoisotopic Mass: 368.231122 Da
Index of Refraction: 1.512
Molar Refractivity: 96.17 cm3
Molar Volume: 320.3 cm3
Surface Tension: 44.9 dyne/cm
Density: 1.15 g/cm3
Flash Point: 278.8 °C
Enthalpy of Vaporization: 89.06 kJ/mol
Boiling Point: 537.4 °C at 760 mmHg
Vapour Pressure: 5.63E-13 mmHg at 25°C
Synonyms: Perindopril ; Perindopril erbumine [USAN] ; (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester, compound with
tert-butylamine (1:1) ; ACEON ; McN-A-2833-109 ; Perindopril erbumine ; Perindopril tert-butylamine ; S-9490-3 ; UNII-1964X464OJ ; 1H-Indole-2-carboxylic acid, 1-(2-((1-
(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, (2S-(1(R*(R*)),2alpha,3abeta,7abeta))-, compd. with 2-methyl-2-propanamine (1:1)
Perindopril erbumine (CAS NO.107133-36-8) can be used as anangiotensin-converting enzyme (ACE) inhibitor.
1. | orl-rat LD :>2500 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 40 (1998),3147. | ||
2. | ivn-rat LD50:323 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 40 (1998),3147. | ||
3. | orl-mus LD :>2500 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 40 (1998),3147. | ||
4. | ivn-mus LD50:323 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 40 (1998),3147. |
A poison by intravenous route. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOx Hazard codes: Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36: Wear suitable protective clothing