Reference

Surface-enhanced Raman spectroscopy of 4-mercaptobenzoic acid

Surface-enhanced Raman spectroscopy of 4-mercaptobenzoic acid. Ji, Yuan; Zhou, Qun; Li, Xiaowei; Zhou, Yaoguo; Zhuang, Yan; Zheng, Junwei (Department of Chemistry, Suzhou University, Suzhou 215006, Peop. Rep. China). Fenxi Huaxue, 32(8), 1050-1052 (Chinese) 2004 Kexue Chubanshe. CODEN: FHHHDT. ISSN: 0253-3820. DOCUMENT TYPE: Journal CA Section: 73 (Optical, Electron, and Mass Spectroscopy and Other Related Properties) Section cross-reference(s): 66, 72 Surface-enhanced Raman spectroscopy of 4-mercaptobenzoic acid was investigated on electrochem. roughened silver electrodes.Several substances with their cas registry numbers 7440-22-4 and 1074-36-8 may be metioned in this study. 4-Mercaptobenzoic acid was adsorbed on the electrode surface via its thiol substituent, the formation of surface Ag-S bond and the structural change of carboxylic acid group have large effect on the electronic structure of benzene ring. The vibrations of carboxylic acid group are sensitive to its protonation, the pKa value of the adsorbed 4-mercaptobenzoic acid was estd. ca. 5.9 from the variation of the intensities of these vibrations with the pH of soln. Copper ion can be coordinated to the adsorbed 4-mercaptobenzate to form surface complex, however, the complexation is dependent on the protonation of the carboxylate group. .

Polyalkyleneamine-containing oligomers for enhanced cellular uptake

Polyalkyleneamine-containing oligomers for enhanced cellular uptake. Manoharan, Muthiah; Guzaev, Andrei P.; Maier, Martin A. (USA ). U. 1074-36-8 and 652975-67-2 are also occured in this study.S. Pat. Appl. Publ. US 2004019000 A1 29 Jan 2004,37 pp. (English). (United States of America). CODEN: USXXCO. CLASS: ICM: A61K048-00. ICS: C07H021-02; C07H021-04; C08G063-48; C08G063-91. NCL: 514044000; 525054200; 536023100. APPLICATION: US 2002-199585 19 Jul 2002. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 34, 35 The present invention relates to novel polyethylenamine-conjugated oligomeric compds., i.e., an oligonucleotide or a peptide nucleic acid and their analogs, and to methods of making such compds. The invention further relates to methods of enhancing the cellular uptake of oligomeric compds. comprising conjugating the compds. to fusogenic moieties and targeting moieties. The fusogenic moiety is selected from a lipophilic polyamine, polyethylenimine, polyallylamine, fusogenic peptide, oligomeric imidazole, histidine, pyridine, hydroxylamine, substituted hydroxylamine, hydrazine, substituted hydrazine, thiourea, or imine. The targeting moiety is a ligand that binds to a cellular receptor, such as transferrin, folate, epidermal growth factor, nerve growth factor, insulin, a-fetoprotein, galactose, galactosamine, lactose, mannose, a polyclonal or monoclonal antibody, vitamin B12, ibuprofen, cholesterol, LDL, or a peptide comprising an arginine-glycine-aspartic acid sequence. For example, prepn. of oligonucleotide conjugates with spermine and polyethylenimines using support-bound oligonucleotides was presented. .