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Detail of "1074-86-8"

  • MSDS Download
  • CAS Number:
  • 1074-86-8
  • Name:

  • Indole-4-carboxaldehyde

  • Molecular Structure:
  • Formula:
  • C9H7NO
  • Molecular Weight:
  • 145.158
  • Synonyms:
  • 4-Formylindole;Indole-4-carbaldehyde;1H-Indole-4-carboxaldehyde;4-Formyl-indole;1H-indole-4-carbaldehyde;
  • Density:
  • 1.278 g/cm3
  • Melting Point:
  • 139-143 °C(lit.)
  • Boiling Point:
  • 339.1 °C at 760 mmHg
  • Flash Point:
  • 166.8 °C
  • Hazard Symbols:
  • HarmfulXn,IrritantXi
  • Risk Codes:
  • 22-36-43
  • Safety:
  • 26-36/37 Details
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Indole-4-carboxaldehyde Purity:98%; Size:5g

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Reference

(4-Phenylpropyl)indole derivatives and their salts and their use as medicines
(4-Phenylpropyl)indole derivatives and their salts and their use as medicines. Clemence, Francois; Guillaume, Jacques; Hamon, Gilles (Roussel-UCLAF , Fr.). Eur. Pat. Appl. EP 201400 A1 17 Dec 1986, 49 pp. DESIGNATED STATES: R: AT, BE, CH, DE, GB, IT, LI, LU, NL, SE. (European Patent Organization) CODEN: EPXXDW. CLASS: ICM: C07D209-08. ICS: C07D209-34; A61K031-40. APPLICATION: EP 86-400884 23 Apr 1986. PRIORITY: FR 85-6135 23 Apr 1985; FR 86-761 21 Jan 1986. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1, 63 The title compds. [I; R, R1 = H, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl; NRR1 may be part of a heterocycle contg. O or N; R2 = H, alkyl; X = OH, H, Y = H or XY = O; R3R4 = O and R5 = H, or R3R5 = bond and R4 = H] and their salts, useful as antiarrhythmics and Ca antagonists, are prepd. 1H-Indole-4-carboxaldehyde was treated with 1-[2-[2-(tert-butylamino)ethoxy]phenyl]ethanone in EtOH contg. NaOH for 4 h to give (E)-4-[3-[2-(tert-butylamino)ethoxy]phenyl]-3-oxo-2-propenyl]-1H-indole. Administration of I to rats (0.05-1 mg/kg i.v.In this study，109920-69-6 is also used. or 0.25-2.5 mg/kg orally) delayed the onset of aconitine-induced arrhythmia by 25-56%. .
A concise synthesis of 5-demethyl-HKI 0231A and 5-demethyl-HKI 0231B
All Rights Reserved. A concise synthesis of 5-demethyl-HKI 0231A and 5-demethyl-HKI 0231B. Kraus, George A.Several reagents such as 1074-86-8 is used here.; Wu, Tao (Department of Chemistry, Iowa State University, Ames, IA 50011, USA). Tetrahedron Letters, 47(44), 7801-7803 (English) 2006 Elsevier Ltd. CODEN: TELEAY. ISSN: 0040-4039. DOCUMENT TYPE: Journal CA Section: 31 (Alkaloids) The pentacyclic skeleton of HKI 0231A and HKI 0231B, I (R = H, OMe), was synthesized by a novel radical cyclization/oxidn. followed by DDQ oxidn. to introduce the methoxyl groups. This is the first synthetic pathway to both the HKI 0231A and the HKI 0231B series. .
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