Detail of "107667-60-7"

Reference

Inflammatory bowel disease preventive and curative agents containing zinc L-carnosine salt or complex

Inflammatory bowel disease preventive and curative agents containing zinc L-carnosine salt or complex. Yoshikawa, Toshikazu; Yoneda, Tomoyuki; Nishimura, Yasuhiro (Zeria Pharmaceutical Co., Ltd.; Hamari Chemicals, Ltd., Japan). Eur. Pat. 305-84-0 and 107667-60-7 are cas registry numbers. These chemicals are also mentioned in this article. Appl. EP 466029 A2 15 Jan 1992, 9 pp. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: A61K031-415. APPLICATION: EP 91-111123 4 Jul 1991. PRIORITY: JP 90-177560 6 Jul 1990. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 Oral dosage forms of L-carnosine salts or complexes are effective for the prevention and treatment of inflammatory bowel diseases by suppressing the bleeding and ulcer of colonic mucosa with extremely low toxicity. A cryst. Zn L-carnosine complex was prepd. by treating L-carnosine with Zn(OAc)2.2H2O and its effectiveness against the inflammatory bowel disease was confirmed by using an exptl. ulcerative colitis model established by administration of dextran Na sulfate to rats. Granules contained Zn L-carnosine complex 50, lactose 315, corn starch 125, and cryst. cellulose 25 g. .

Changes in zinc, copper, and iron contents in the body after long-term oral administration of zinc preparations

Changes in zinc, copper, and iron contents in the body after long-term oral administration of zinc preparations. Ito, Atsuko (Sch. Med., Toho Univ., Tokyo, Japan). Yakuri to Chiryo, 14(11), 6891-7 (Japanese) 1986. CODEN: YACHDS. ISSN: 0386-3603.Several reagents with their cas registry numbers 107667-60-7 and 7439-89-6 are used here. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 18 In rats following oral administration of the Zn prepn. N-(3-aminopropionyl)-L-histidine zinc [107667-60-7] (300 mg/kg/day 6 times weekly for 10 wk), Zn was accumulated in the body at early stage, but the metab. of Zn was normal after 8 wk, and no big changes in Zn, Cu, and Fe contents in the blood, feces, urine liver, kidneys, and spleen were noted; however Zn absorption and Cu content in the organs were slightly decreased after 8 wk. No other changes in body wt gain, blood enzymes and biochem. and histopathol. tests were obsd. Apparently, the Zn prepn. has high therapeutic index. .