Detail of "107865-24-7"

CAS Number:
107865-24-7
Name:
L-Tyrosine,N-[N-[N-[N2-[N2-[[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)amino]thioxomethyl]-L-arginyl]-L-lysyl]-L-a-aspartyl]-L-valyl]- (9CI)
Molecular Structure:
Formula:
C51H60 N10 O14 S
Molecular Weight:
0
Synonyms:
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene],L-tyrosine deriv.
Density:
1.53g/cm³
Boiling Point:
°Cat760mmHg
Flash Point:
°C

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Synthesis of two biologically active fluorescent probes of thymopentin: Synthesis of two biologically active fluorescent probes of thymopentin. Amoscato, Andrew A.; Babcock, George F.; Sramkoski, R. Michael; Hynd, Barbara A.; Alexander, J. Wesley (Coll. Med., Univ. Cincinnati, Cincinnati, OH 45267-0558, USA). Int. J. Pept. Protein Res., 29(2), 177-86 (English) 1987. CODEN: IJPPC3. ISSN: 0367-8377. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The synthesis of 2 fluorescent analogs of thymopentin (TP-5) [69558-55-0] is reported. A fluorescein-isothiocyanate-labeled analog (FITC-TP-5) [107865-24-7] and a stilbene-isothiocyanate-labeled analog (SITS-TP-5) [107878-40-0] were extensively purified by ion-exchange and gel-filtration chromatog. 107865-24-7 and 69558-55-0 which are cas registry numbers of chemicals are mentioned. Characterization of the coupling site through amino acid anal., dansylation, and N-terminal cleavage of the fluorescent amino acid yielded results which indicated that both were mono-labeled analog derivatized at the N-terminal. These analogs were TP-5-like in nature since they induced the expression of the Thy 1.2 surface marker on nude mouse prothymocytes in both in vivo and in vitro assays. In addn., these analog inhibited the specific binding of radiolabeled TP-5 to human lymphocytes. Initial studies describing the interaction of FITC-TP-5 with human lymphocytes are shown. .