Detail of "108-16-7"

Reference

Protection of murine L1210 leukemia and bone marrow progenitor cells against mechlorethamine and inhibition of choline uptake as a structure-activity relationship of 2-dimethylaminoethanol and its analogs

Protection of murine L1210 leukemia and bone marrow progenitor cells against mechlorethamine and inhibition of choline uptake as a structure-activity relationship of 2-dimethylaminoethanol and its analogs. Naujokaitis, Saulius A.; Fisher, Joyce M.; Rabinovitz, Marco (Lab. Med. Chem. Pharmacol., Natl. Cancer Inst.There are some reagents with their cas registry numbers 100-37-8 and 102-81-8 are used in this study., Bethesda, MD 20850, USA). J. Pharm. Sci., 73(1), 34-9 (English) 1984. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The structure-activity relationships of 2-dimethylaminoethanol [108-01-0] and its analogs as protectors against mechlorethamine [51-75-2] cytotoxicity and as inhibitors of choline [62-49-7] uptake were evaluated. Of a series of inhibitors and protectors, 2-dimethylaminoethanol was the most potent inhibitor of choline uptake and the most potent protector of both hematopoietic progenitor cells and murine L1210 leukemia cells. Two analogs that exhibited both potent protection and inhibition were 1-dimethylamino-2-propanol [108-16-7] and 2-ethylmethylaminoethanol [2893-43-8]. 2-Di-n-butylaminoethanol [102-81-8], while protecting against mechlorethamine cytotoxicity, was not an inhibitor of choline uptake. 2-(n-Butylmethylamino)ethanol [2893-48-3], while an inhibitor of choline uptake, was not a protector against mechlorethamine cytotoxicity. Addn. of 2-dimethylaminoethanol to mechlorethamine in a mole ratio of 1 did not improve survival of tumor-bearing mice beyond that of mice treated with mechlorethamine alone. .

Cationic polyelectrolytes

Cationic polyelectrolytes. V. On macromolecular chain conformational state during amination reactions of CMPS. Dragan, Stela; Ioan, Silvia; Petrariu, I.; Dima, M. (Inst. Macromol. Chem. "Petru Poni", Iasi 6600, Rom.). J. Polym. Sci., Polym. Chem. Ed., 23(5), 1267-81 (English) 1985. CODEN: JPLCAT. ISSN: 0449-296X. DOCUMENT TYPE: Journal CA Section: 36 (Physical Properties of Synthetic High Polymers) Section cross-reference(s): 35 The conformational state during the amination of chloromethylated polystyrene (CMPS) with methyl(2-hydroxyethyl)amine [109-83-1] and N,N-dimethyl(2-hydroxypropyl)amine [108-16-7] was studied. Viscometric and light-scattering measurements were performed during reactions in DMSO binary solvent mixts. The obsd. kinetic deviations were related to conformational transformations.