CAS No.108-48-5,2,6-Lutidine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	108-48-5
Name:	2,6-Lutidine
Article Data:	120

Formula:	C₇H₉N
Molecular Weight:	107.155
Synonyms:	a,a'-Lutidine;2,6-Dimethylpyridine;NSC 2155;a,a'-Dimethylpyridine;2,6-Lutidine(8CI);
EINECS:	203-587-3
Density:	0.9252 g/cm³
Melting Point:	-6 °C
Boiling Point:	144 °C at 760 mmHg
Flash Point:	33.3 °C
Solubility:	40 g/100 mL (20 °C) in water
Appearance:	Colorless to yellow liquid
Hazard Symbols:	Xn
Risk Codes:	10-22-36/37/38-20/21/22
Safety:	26-36/37-16-36-36/37/39
Transport Information:	UN 1993 3/PG 3
PSA:	12.89000
LogP:	1.69840

Synthetic route

: 108-48-5
2,6-dimethylpyridine

: C25H12BF18N

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

A: 108-48-5
2,6-dimethylpyridine

B

C

Conditions

Conditions	Yield
In hexane at 60℃; for 10h;	A n/a B n/a C 68%

...Expand

2.6-bis(hydroxymethyl)pyridine: 2.6-bis(hydroxymethyl)pyridine

A: 108-48-5
2,6-dimethylpyridine

B: 1122-71-0
2-(Hydroxymethyl)-6-methylpyridine

Conditions

Conditions	Yield
With [IrCl(CO)(PPh3)2]; hydrazine hydrate; potassium hydroxide In methanol at 160℃; for 3h; Wolff-Kishner Reduction; Sealed tube;	A 64% B 10%

: 67-64-1
acetone

: 74-86-2
acetylene

A: 109-06-8
α-picoline

B: 108-48-5
2,6-dimethylpyridine

C: 108-75-8
2,4,6-trimethyl-pyridine

D: 108-47-4
2,4-lutidine

Conditions

Conditions	Yield
With ammonia; MG-4 at 375℃; under 760 Torr;	A 6.3% B 7.3% C 58.3% D 5.9%
With ammonia; MG-4 at 375℃; under 760 Torr; Product distribution; other catalysts;	A 6.3% B 7.3% C 58.3% D 5.9%
With ammonia; MG-4 at 350℃; under 760 Torr;	A 6.2% B 15.6% C 36.4% D 6.8%

...Expand

: 504-03-0
2.6-dimethylpiperidine

: 108-48-5
2,6-dimethylpyridine

Conditions

Conditions	Yield
With [iPrPN(H)P]2Fe(H)(CO)(BH4) In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 30h; Inert atmosphere; Schlenk technique; Glovebox;	58%
With OsH3(acac)(PiPr3)2 In para-xylene at 140℃; for 48h; Schlenk technique; Irradiation;	29 %Chromat.
With Cp*Ir(6,6'-dionato-2,2'-bipyridine)(H2O) In para-xylene for 20h; Reflux; Inert atmosphere; Schlenk technique;	88 %Chromat.
In octane at 120℃; under 760.051 Torr; for 18h; Inert atmosphere; Schlenk technique;	>99 %Chromat.
With tert-butylethylene; C21H26ClIrNOP; sodium t-butanolate In para-xylene at 150℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;	88 %Chromat.

: 598-32-3
2-hydroxy-3-butene

: 18312-45-3
propan-2-one O-acetyl oxime

: 108-48-5
2,6-dimethylpyridine

Conditions

Conditions	Yield
With oxygen; copper diacetate; palladium diacetate; potassium carbonate In acetonitrile at 80℃; under 760.051 Torr; Heck Reaction;	52%

: 1073-23-0
2,6-lutidine N-oxide

: 16420-13-6
N,N-Dimethylthiocarbamoyl chloride

A: 108-48-5
2,6-dimethylpyridine

B: C10H14N2OS

Conditions

Conditions	Yield
In acetonitrile at 81℃; for 4h;	A 51% B 14%

...Expand

: 78-93-3
butanone

A: 108-48-5
2,6-dimethylpyridine

B: 583-61-9
2,3-Lutidine

C: 1462-84-6
2,3,6-trimethylpyridine

D: 2233-29-6
2,3,4-lutidine

Conditions

Conditions	Yield
With ammonia; chromium(III) oxide; aluminium at 375℃;	A 6.8% B 24.6% C 45.4% D 25.7%
With ammonia; chromium(III) oxide; aluminium at 425℃;	A 25.3% B 34.5% C 13.8% D 13.8%
With ammonia; chromium(III) oxide; aluminium at 450℃;	A 21.8% B 22.4% C 29.4% D 11.7%
With ammonia; chromium(III) oxide; aluminium at 300 - 450℃; Product distribution;

...Expand

: 87117-15-5
1-methoxy-2,6-dimethylpyridinium methyl sulfate

A: 108-48-5
2,6-dimethylpyridine

B: 696-44-6
N-methyl-m-toluidine

Conditions

Conditions	Yield
With Dimethylammonium sulphite In water at 150℃; for 24h;	A 20% B 42%

: 20451-53-0
Phenyl vinyl sulfoxide

: 77202-09-6
4,6-dimethyl-1,2,3-triazine

A: 108-48-5
2,6-dimethylpyridine

B: 108-47-4
2,4-lutidine

Conditions

Conditions	Yield
at 180℃; 1-2.5 h;	A n/a B 35%

...Expand

Raw Materials

2602-36-0

585-48-8

583-61-9

7647-01-0

111-66-0

3999-42-6

13505-34-5

75-36-5

Downstream Products

3099-28-3

68470-59-7

107-40-4

493-77-6

3512-75-2

144-62-7

56533-57-4

2525-19-1

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Chemistry

Molecular Formula: C₇H₉N

Formula Weight: 107.15
mp of 2,6-LUTIDINE (108-48-5): -6 ^°C
bp : 143-145 ^°C(lit.)
density : 0.92 g/mL at 25 ^°C(lit.)
refractive index : n20/D 1.497(lit.)
Fp of 2,6-LUTIDINE (108-48-5): 92 ^°F
storage temp. : -20^°C
Water Solubility : 40 g/100 mL (20 ^oC)
Odor: Characteristic.
Color: Straw color.
Solubility: Easily soluble in cold water.
2,6-LUTIDINE (108-48-5) is a colorless to yellow oily liquid.

Uses

In organic synthesis, 2,6-LUTIDINE (108-48-5) is widely used as a sterically hindered mild base. It is also used as a vulcanization accelerator for pesticides, dyes, dyes, resins and rubber. And also can be used as a solvent.

Production

Recycling β-methylpyridine fractions from coal by-products of coking, then separating β-methylpyridine fractions, we can obtain 2,6-LUTIDINE (108-48-5).

Toxicity Data With Reference

1.	sln-smc 5000 ppm	MUREAV Mutation Research. 163 (1986),23.
2.	orl-rat LD50:400 mg/kg	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,845.
3.	ihl-rat LCLo:7500 ppm/1H	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,845.
4.	skn-gpg LD50:2500 mg/kg	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,845.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Hazard Codes : Xn,F,Xi (Harmful; Highly Flammable; Irritant)
Risk Statements : 10-22-36/37/38-20/21/22 (Flammable; Harmful if swallowed; Irritating to eyes, respiratory system and skin; Harmful by inhalation, in contact with skin and if swallowed)
Safety Statements : 26-36/37-16-36-36/37/39 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing and gloves; Keep away from sources of ignition - No smoking; Wear suitable protective clothing; Wear suitable protective clothing, gloves and eye/face protection)
RIDADR : UN 1993 3/PG 3
WGK Germany : 3
RTECS : OK9700000
F : 8 (Photosensitive)
Hazard Note : Irritant/Flammable
HazardClass : 3
PackingGroup : III
HS Code : 29333999
Poison by ingestion. Moderately toxic by skin contact. Mildly toxic by inhalation. Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x.

Specification

Storage: Keep container tightly closed. Keep in a cool, well-ventilated place. Keep away from heat. Keep
away from sources of ignition. A refrigerated room would be preferable for materials with a flash point lower than
37.8^°C (100^°F). Flammable materials should be stored in a separate safety storage cabinet or room. Ground all
equipment containing material.