Detail of "108-79-2"

Reference

Structure, cyclization, and other properties of the electrochemical reduction product of 4,6-dimethylpyrimidone-2

Structure, cyclization, and other properties of the electrochemical reduction product of 4,6-dimethylpyrimidone-2. Czochralska, Barbara; Shugar, David; Arora, Satish K.; Bates, Robert B.; Cutler, Robert S. (Inst. Exp. Phys., Univ. Warsaw, Warsaw, Pol.). J. Am. Chem. Soc., 99(8), 2583-8 (English) 1977. CODEN: JACSAT. DOCUMENT TYPE: Journal CA Section: 72 (Electrochemistry) Section cross-reference(s): 75 At the dropping Hg electrode in neutral aq. medium 4,6-dimethyl-2-pyrimidone [108-79-2] undergoes 1-electron redn. to 6,6'-bis(3,6-dihydro-4,6-dimethyl-2-pyrimidone) [62700-66-7]. This product C12H18N4O, also obtained by UV irradn. of the pyrimidone in 2-propanol, crystallizes with 2 mols. of EtOH in space group P2/c with a 9.111(2), b 7.170(3), c 15.775(5) .In this article, certain chemicals are used. Some of their cas registry numbers are 62700-68-9 and 62700-66-7 ANG., .beta. 112.70(2).degree., and Z = 2; an x-ray study (final R = 0.044) reveals it to be mesa. It undergoes photochem. dissocn. in water at 254 nm with a quantum yield of 0.03 to quant. regenerate the parent monomer, and in dil. acid adds a water moll. with cyclization. The cyclization product, C12H20N4O3.2H2O, crystallizes in space group Pca21 with a 9.206(3), b 11.482(3), c 14.180(7) .ANG. and Z = 4; an x-ray study (final R = 0.037) shows the previously assigned struture to be incorrect and gives the true structure. The H-bonding arrangement in this crystal includes base-pairing and a bifurcate H bond. .

Kinetics and mechanism of degradation of some 2-sulfanilamidopyrimidine derivatives

Kinetics and mechanism of degradation of some 2-sulfanilamidopyrimidine derivatives. Part 1. Log k-pH profile for sulfadimidine solvolysis.Several substances are used for example 63-74-1 and 108-79-2 which are their cas registry numbers. Zajac, Maria (Inst. Chem. Anal., Med. Acad., Poznan, Pol.). Pol. J. Pharmacol. Pharm., 28(5), 495-503 (English) 1976. CODEN: PJPPAA. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The well-differentiated UV spectra of Na sulfadimidine (I) [1981-58-4], sulfanilamide (II) [63-74-1], and 2-hydroxy-4,6-dimethylpyrimidine (III) [108-79-2], in 0.1 M HCl, enabled monitoring of the degrdn. of I to II and III and of the further degrdn. of III as function of pH and temp. Rate consts. k1 and k2 for the degrdns. of I anad III, resp., in the pH range 5.83-9.96 at 403, 411, and 418 K were calcd. from the changes in absorbance vs. time for I (at 243 nm) and III (at 302 nm). The log k-pH profiles for I and III were then used to calc. sp. rate consts. and pKa values. Thermodn. parameters such as energy, enthalpy, entropy of activation, and the frequency factor for the investigated reaction were calcd. from the sp. rate consts. for hydrolysis of I and III. .