Reference

In vitro antibacterial properties of EL-870, a new semisynthetic macrolide antibiotic

In vitro antibacterial properties of EL-870, a new semisynthetic macrolide antibiotic. Ose, E. E. (Eli Lilly and Co., Greenfield, IN 46140, USA). J. Antibiot., 40(2), 190-4 (English) 1987. CODEN: JANTAJ. ISSN: 0021-8820. DOCUMENT TYPE: Journal CA Section: 10 (Microbial Biochemistry) Section cross-reference(s): 26 A new macrolide antibiotic, EL-870 (I), 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin, has been prepd. by chem. modification of desmycosin. In vitro, against selected animal bacterial pathogens, it inhibited growth of Pasteurella multocida, P. haemolytica, Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Streptococcus suis, Actinomyces pyogenes and certain other bacteria at levels of ￡6.25 mg/mL. In general, the min. inhibitory concns. (MICs) for gram-neg. enteric bacteria have been >50 mg/mL. Concns. equiv. to 4′ the MIC value were bactericidal for Pasteurella sp. I had other antibacterial properties which were characteristic of macrolide antibiotics.Except for chemicals metioned above, 108050-54-0 is also used. .

Analysis of tilmicosin by high performance liquid chromatography

Analysis of tilmicosin by high performance liquid chromatography. Zhang, Xudong; Lu, Rui'e; Zhang, Baoguo (Department of Chemistry, Zhengzhou University, Zhengzhou 450052, Peop. Rep. China). Zhengzhou Daxue Xuebao, Lixueban, 35(3), 70-72 (Chinese) 2003 Zhengzhou Daxue Xuebao, Lixueban Bianjibu. CODEN: ZDXLA4. ISSN: 1671-6841. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) The anal. method of tilmicosin by high performance liq. chromatog. (HPLC) was developed with the mobile phase of water, acetonitrile, THF and phosphoric acid-butylamine, the flow-rate of 1 mL/min, the column of ODS (4.6 mm ′ 200 mm, 5 mm) and the detection wavelength of 280 nm. Under the optimal condition, the retention time of Tilmicosin is 6.5 min and 7. There are some commonly used reagents like 108050-54-0 in this article.5 min (maleinoid form and transform), the low detection limit is 1.7 mg. This method is simple, rapid and of good stability, which can be used to det. the batch samples. .