Name: TEMAFLOXACIN
SKU: 108319-06-8

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Basic Information

Molecular Structure:
CAS No.:	108319-06-8
Name:	TEMAFLOXACIN
Article Data:	2

Formula:	C21H18 F3 N3 O3
Molecular Weight:	417.387
Synonyms:	(?à)-Temafloxacin;1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylicacid; A 62254; A 63004; T 1258; Teflox; Temac; Temafloxacin
Density:	1.427g/cm³
Boiling Point:	608.9°Cat760mmHg
Flash Point:	322.1°C
Safety:	Mutation data reported. When heated to decomposition it emits toxic vapors of F⁻ and Cl⁻.
PSA:	74.57000
LogP:	3.29810

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Chemistry

IUPAC Name: 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Synonyms: 1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid ; 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ; 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-
CAS NO: 108319-06-8
Molecular Formula of Temafloxacin (CAS NO.108319-06-8): C₂₁H₁₈F₃N₃O₃
Molecular Weight of Temafloxacin (CAS NO.108319-06-8) : 417.38
Molecular Structure of Temafloxacin (CAS NO.108319-06-8) :
Index of Refraction: 1.603
Surface Tension: 52.6 dyne/cm
Density: 1.427 g/cm³
Flash Point: 322.1 °C
Enthalpy of Vaporization: 95.11 kJ/mol
Boiling Point: 608.9 °C at 760 mmHg
Vapour Pressure: 1.11E-15 mmHg at 25°C
Appearance: ethanol in the crystal,
Melting point :274-276°C

Uses

Temafloxacin (CAS NO.108319-06-8) is used as antibacterial drugs for lower respiratory tract infections and urinary tract infections, sexually transmitted diseases, skin and soft tissue infections.

Production

Raw materials :Sodium hydride -->1,2-Dimethoxyethane-->Diethyl carbonate-->2,4-Difluoroaniline-->2,4-Dichloro-5-fluoroacetophenone-->2-Methylpiperazine
Condensation of 2,4 - Dichloro--5 - Fluoroacetophenone and Diethyl carbonate , then condensation with Triethyl orthoformate , and then, condensation with 2,4 - Difluoro-aniline . Then, reflux and cyclization in Ethylene glycol dimethyl ether in the presence of Sodium hydride . After hydrolysis, condensation with 2 - Methyl-piperazine ,obtaining Temafloxacin (CAS NO.108319-06-8).

Toxicity Data With Reference

1.		mic-bac-sat 60 µg/L AACHAX 37,213,93
2.		uns-bac-esc 50 µg/L AACHAX 37,213,93
3.		pic-bac-esc 50 µg/L AACHAX 37,213,93
4.		dnr-bcs 20 mg/L AACHAX 37,213,93

Safety Profile

Mutation data reported. When heated to decomposition it emits toxic vapors of F⁻ and Cl⁻.