Detail of "1088-11-5"

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CAS Number:
1088-11-5
Name:
Nordazepam
Molecular Structure:
Formula:
C₁₅H₁₁ClN₂O
Molecular Weight:
270.71
Synonyms:
1-Demethyldiazepam;7-Chloro-1,3-dihydro-1H-5-phenyl-2H-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-5-phenyl-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazapin-2-one;7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one;7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one;7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-Chloro-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one;7-Chloro-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one;7-Chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one;7-Chloro-5-phenyl-2-oxo-1,2-dihydro-1,4-benzodiazepine;7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one;Calmday;DMDZ;Dealkylprazepam;Demethyldiazepam;Demoxazepam;Desalkylprazepam;Desmethyldiazepam;Madar;N-Demethyldiazepam;N-Deoxydemoxepam;N-Descyclopropylmethylprazepam;N-Desmethyldiazepam;N1-Desmethyldiazepam;NSC 46078;NSC 631619;Nordaz;Norprazepam;Praxadium;Ro 5-2180;Stilny;
EINECS:
214-123-4
Density:
1.323 g/cm³
Melting Point:
208-210°C
Boiling Point:
453.103 °C at 760 mmHg
Flash Point:
227.829 °C
Appearance:
Off-white solid
Hazard Symbols:
Xn,T,F
Risk Codes:
22-39/23/24/25-23/24/25-11
Safety:
7-16-36/37-45 Details
Transport Information:
UN 3249

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Pharmacokinetics of pinazepam in healthy volunteers: Pharmacokinetics of pinazepam in healthy volunteers. Pacifici, G. M.; Placidi, G. F.; Fornaro, P.; Gomeni, R. (Inst.Chemicals with cas numbers 56305-05-6 and 604-75-1 also play role. Gen. Pathol., Univ. Pisa, Pisa, Italy). Int. J. Clin. Pharmacol. Res., 3(5), 331-7 (English) 1983. CODEN: CPHRDE. ISSN: 0251-1649. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The kinetics of pinazepam [52463-83-9] were studied in healthy volunteers after a single oral 10-mg dose. Plasma levels of pinazepam were fitted to a 2-compartment open model with 1st order absorption rate using a 3-exponential equation. The absorption rate const. and peak plasma levels of pinazepam were 1.36 and 36.8 ng/mL, resp. Plasma decay of the drug consisted of an initial rapid elimination phase (a = 0.46/h) followed by a slow one (b = 0.046 h). N-Desmethyldiazepam [1088-11-5] was the only metabolite detected in the plasma; its plasma concns. were higher than those of the parent compd. shortly after administration. Urine collected 72 h after drug administration contained unconjugated pinazepam and N-desmethyldiazepam, oxazepam glucuronate [6801-81-6], and 3-hydroxypinazepam glucuronate [62488-23-7]. Only 0.016% of the pinazepam administered was recovered as the unchanged compd. in the urine. .

Clinical laboratory aspects of therapeutic monitoring for benzodiazepines: Clinical laboratory aspects of therapeutic monitoring for benzodiazepines. Lascelles, Peter T.Several substances are used for example 12794-10-4 and 22316-47-8 which are their cas registry numbers. (Natl. Hosp. Nerv. Dis., London, UK). Benzodiazepines Divided: Multidiscip. Rev., Beecham Symp., Meeting Date 1982, 209-27. Edited by: Trimble, Michael R. Wiley: Chichester, UK. (English) 1983. CODEN: 50PQAK. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) The results obtained on the detn. of diazepam [439-14-5], demethyldiazepam [1088-11-5], and clobazam [22316-47-8] by a radioreceptor method are discussed. Comparisons are made with high-performance liq. chromatog. for the detn. of benzodiazepines in plasma. Other anal. methods for the detn. of these drugs are reviewed. .