Detail of "109-07-9"

CAS Number:
109-07-9
Name:
Piperazine,2-methyl-
Superlist Name:
2-Methylpiperazine
Molecular Structure:
Formula:
C₅H₁₂N₂
Molecular Weight:
100.16
Deleted CAS:
75364-79-3
Synonyms:
Piperazine,2-methyl-, (?à)-;(?à)-2-Methylpiperazine;2-Methylpiperazine;NSC 5277;
EINECS:
203-644-2
Density:
0.845 g/cm³
Melting Point:
61-63 °C(lit.)
Boiling Point:
153.2 °C at 760 mmHg
Flash Point:
45.1 °C
Solubility:
78 g/100 mL (25 °C) in water
Appearance:
white to yellow crystalline powder and chunks
Hazard Symbols:
F,Xi
Risk Codes:
11-36/37/38
Safety:
16-26-36/37/39-36 Details
Transport Information:
UN 1325 4.1/PG 2
particular:
particular

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Reference

C-Alkylpiperazines structurally related to piribedil: C-Alkylpiperazines structurally related to piribedil. XI. Sanna, P.; Loriga, M.; Cignarella, G.; Ferni, G. (Ist. Chim. Farm. Tossicol., Univ. Sassari, Sassari, Italy). Farmaco, Ed. Sci., 40(7), 477-85 (English) 1985. CODEN: FRPSAX. ISSN: 0430-0920. 109-07-9 is the cas registry number of certain chemical which is used as reagents here. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 28 A series of 2-Me or 2,6-di-Me substituted 1-alkoxybenzyl-4-(pyrimidyl)piperazines I (R = H or Me; R1 and R4 = H or OMe; R2 = R3 = OMe or R2R3 = OCH2O) was prepd. by condensing 2-methyl- [109-07-9] or cis- [21655-48-1] or trans-2,6-dimethylpiperazines [2815-34-1] with 2-chloropyrimidine [1722-12-9] to give the corresponding 1-(2-pyrimidyl)piperazines which were reacted with the appropriate alkyloxybenzyl bromide. 1-(2-Pyrimidyl)-4-(3,4-dimethoxybenzyl)-2-methylpiperazine (II) [97993-28-7] was obtained by condensing 2-methylpiperazine with 3,4-dimethoxybenzyl bromide [21852-32-4] to give 1-(3,4-dimethoxybenzyl)-3-methylpiperazine [97993-29-8] which is reacted with 2-chloropyrimidine, yielding II. None of the compds. had any a-adrenolytic activity. Only 2 of the compds. had dopaminergic activity as detd. by increased mouse motility in reserpinized mice, but the activity of these compds. was not further confirmed by other tests predictive of central dopaminergic activity. II was a more potent vasodilator than piribedil, but such activity did not appear to be correlated with a-adrenolytic or dopaminergic activities. .

Synthesis and antileukemic properties of 2-methyl and 2,5-dimethylpiperazides: Synthesis and antileukemic properties of 2-methyl and 2,5-dimethylpiperazides. Groszkowski, Stefan; Najman, Liliana (Dep. Pharm. Chem. Anal. Drugs, Med. Acad., Lodz 90-145, Pol.). Pol. J.Except for chemicals metioned above, 36680-08-7 is also used. Pharmacol. Pharm., 35(6), 517-21 (English) 1983. CODEN: PJPPAA. ISSN: 0301-0244. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 28 A series of 15 piperazides (I; R = H or Me; R1 = Me, Et, Pr, Bu etc.) were prepd. as analogs of the antileukemic drug NSC 337310 (II) [36680-08-7] by treatment of 2-Me- [109-07-9] or 2,5-dimethylpiperazine [106-55-8] with monoalkyl maleoyl chlorides. Only II showed activity against P 388 leukemia in animals (not specified). Structure-activity relations are discussed. .

Detail of "109-07-9"

Piperazine,2-methyl-

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CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

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CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

CAS No.109-07-9 2-Methylpiperazine

Reference