Reference

Reaction of chlorohydrocarbons

Reaction of chlorohydrocarbons. XXXI. Methoxylation of 1,3-dihalopropanes with methanol over activated alumina catalyst. Shinoda, Kiyonori; Yasuda, Kensei (Toyama Tech. 109-70-6 and 1344-28-1 are also occured in this study. Coll., Toyama 930-11, Japan). Nippon Kagaku Kaishi, (12), 1698-702 (Japanese) 1983. CODEN: NKAKB8. ISSN: 0369-4577. DOCUMENT TYPE: Journal CA Section: 23 (Aliphatic Compounds) Br(CH2)3Cl (I) was methoxylated with MeOH over activated Al2O3 to MeO(CH2)3X (X = halo, OMe), and the catalytic reaction was accompanied by disproportionation of I into X(CH2)3X [X = Br (II), Cl (III)] at 160-280°. No dehydrohalogenation of I to allyl halides was obsd. in this reaction. Since halogen atoms were converted into Me halides, methoxylation of I was always more favorable than disproportionation of I into II and III. The degree of methoxylation was almost const. with increasing MeOH-I molar ratio. The yield of methoxylation products increased with the temp. and contact time. The Br atom in I was replaced preferentially to the Cl atom by the MeO group. The kinetic results obtained also indicated the lower reactivity of 1,3-dihalopropanes in the following order: II > I ? III. MeO- ion generated on the basic sites of activated Al2O3 attacks the terminal C atom of I via an SN2 mechanism. .

Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A New Class of Agents with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Who Were Imatinib-Resistant

All Rights Reserved. Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A New Class of Agents with High Apoptotic Activity in Chronic Myelogenous Leukemia K562 Cells and in Cells from Patients at Onset and Who Were Imatinib-Resistant. [Erratum to document cited in CA]. Silvestri, Romano; Marfe, Gabriella; Artico, Marino; La Regina, Giuseppe; Lavecchia, Antonio; Novellino, Ettore; Morgante, Emanuela; Di Stefano, Carla; Catalano, Gianfranco; Filomeni, Giuseppe; Abruzzese, Elisabetta; Ciriolo, Maria Rosa; Russo, Matteo Antonio; Amadori, Sergio; Cirilli, Roberto; La Torre, Francesco; Sinibaldi Salimei, Paola (Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universita La Sapienza, Rome I-00185, Italy). Journal of Medicinal Chemistry, 49(24), 7252 (English) 2006 American Chemical Society. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 28 The name of the seventh author, Emanuela Morgante, was misspelled as "Manuela Morgante".In this experiment, several chemicals are used like 879-18-5 .