Detail of "1094-08-2"

Reference

Conformational study of three 10-substituted phenothiazines

Conformational study of three 10-substituted phenothiazines. Correlations with their biological properties, and especially their antiparkinson activity.Several substances are used for example 522-24-7 and 60-91-3 which are their cas registry numbers. Barbe, Jacques; Blanc, Alain; Chauvet-Monges, Anne Marie (Lab. Chim. Miner., U.E.R. Pharm., Marseille, Fr.). C. R. Hebd. Seances Acad. Sci., Ser. C, 284(3), 109-12 (French) 1977. CODEN: CHDCAQ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Dipole moments and NMR spectra were detd. for diethazine [60-91-3], fenethazine [522-24-7], and isothiazine [1094-08-2] and correlated with their pharmacol. activity. A privileged spatial structure of the intrafolded H type apparently exists, and the antiparkinson activity of the compds. may be due to this globular conformer. .

Electronic properties of N-heteroaromatics

Electronic properties of N-heteroaromatics. LX. Oxidation of oxyhemoglobin in the presence of phenothiazine tranquilizers: formation of methemoglobin and its mechanism. Okano, Teisuke; Haga, Makoto; Takashi, Katsuo; Nakamoto, Sachiko; Motohashi, Noboru (Pharm. Inst., Tohoku Univ., Sendai, Japan). Yakugaku Zasshi, 97(4), 430-9 (Japanese) 1977. CODEN: YKKZAJ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Studies were made on the oxidn. of oxyhemoglobin (HbO2) by the presence of phenothiazine system tranquilizers. Methemoglobin (MHb) was formed when ethopropazine-HCl (I) [1094-08-2], promethazine-HCl (II) [58-33-3], promazine-HCl (III) [53-60-1], or perazine (VI) [84-97-9] was incubated with a suspension of human erythrocytes or with HbO2 soln. obtained through hemolysis of this suspension. In either of the expts. with erythrocytes and HbO2 soln., the MHb-forming effect of the compd. decreased in the order of I, II, III, and VI. The HbO2-oxidizing activity of these derivs. was enhanced when they were photoirradiated before mixing of the derivs. with HbO2 soln. Chlorpromazine-HCl [69-09-0], methoxypromazine maleate [3403-42-7], thioperazine dimethanesulfonate [2347-80-0], fluphenazine dimaleate [3093-66-1], trimeprazine tartrate [2015-31-8], and methotrimeprazine-HCl [7558-51-2] formed MHb when their acid solns. were photoirradiated before their incubation with HbO2 soln.. The HbO2-oxidizing activity of phenothiazine derivs. was also enhanced when they were subjected to potentiostatic electrolysis or pyrolysis. The amt. of MHb formed in the incubation mixt. paralleled the amt. of semiquinone free radicals produced from the derivs. On the basis of the results of comparative examns. on the HbO2-oxidizing activity, spectral change in the UV and visible regions, and polarog. half-wave potentials of the derivs., it was presumed that, in the case where untreated phenothiazine derivs. were involved, cation radicals produced by some oxidizing substance in the incubation mixt. played an important role in the formation of MHb from HbO2.