Detail of "1098-97-1"

Reference

The effects of various drugs on the motor performance capacity of old rats

The effects of various drugs on the motor performance capacity of old rats. Jaenicke, B.; Wrobel, D.; Schulze, G. (Dep. Neuropsychopharmacol., Free Univ. Berlin, Berlin D-1000/19, Fed. Rep. Ger.). Pharmacopsychiatry, 18(1), 136-7 (English) 1985. CODEN: PHRMEZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The performance of 28-mo-old rats on the rotarod test (20 rpm) were improved by at least 50% after 6 wk of treatment with daily pyrithioxin [1098-97-1] (50 mg/kg), centrophenoxine [3685-84-5] (100 mg/kg) or Ro 13-5057 [75878-25-0] (30 mg/kg); the improvement in piracetam [7491-74-9] (250 mg/kg) or Hydergin [8067-24-1] (0.5 mg/kg)-treated rats was 25-40%. In contrast, d-amphetamine [51-64-9] (3 mg/kg) impaired performance on the rotarod test. The spontaneous activity values of the open-field test and motor tasks, except for the rotarod test (20 rpm), of 27-mo-old rats did not vary from those of 4-mo-old rats. Thus, even rats older than the 50% survival age (27 mo), can become accustomed to a broad range of motor tasks. However, the range of improvement becomes limited with increasing task complexity. In addn., drugs can improve performance beyond that acquired from practice alone.

Facilitation of transcallosal evoked potentials by nootropics

Facilitation of transcallosal evoked potentials by nootropics. Kirsch, U.; Schmidt, J. (Inst. Pharmakol. Toxikol., Med. Akad. "Carl Gustav Carus", Dresden 8010, Ger. Dem. Rep.). Biomed. Biochim. Acta, 44(4), 631-6 (German) 1985. CODEN: BBIADT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effect of nootropic drugs was investigated by studying their influences on transcallosal evoked potentials in rats. Piracetam [7491-74-9], meclofenoxate [51-68-3], vinpocetine [42971-09-5], pyritinol [1098-97-1], orotic acid [65-86-1], and dihydroergotoxine [11032-41-0] as well as the latter's components, dihydroergocornine [25447-65-8] and dihydroergocryptine [25447-66-9], enhanced in a dose-dependent manner the amplitudes of the responses. The evoked potentials remained unchanged after dihydroergocristine [17479-19-5] and nicergoline [27848-84-6] at the dosage used.