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Basic Information
| CAS No.: | 110-52-1 |
|---|---|
| Name: | 1,4-Dibromobutane |
| Article Data: | 96 |
| Molecular Structure: | |
|
|
|
| Formula: | C4H8Br2 |
| Molecular Weight: | 215.916 |
| Synonyms: | 1,4-Dibrombutan;DBB;1,4 Dibromo Butane;1,4-Butylene Bromide;1,4-Dibromobutane / Tetramethylene Dibromide;1,4-Dibromobutene;Tetramethylene dibromide;Butane, 1,4-dibromo-;Butane,1,4-dibromo-; |
| EINECS: | 203-775-5 |
| Density: | 1.785 g/cm3 |
| Melting Point: | - 20 °C(lit.) |
| Boiling Point: | 197 °C at 760 mmHg |
| Flash Point: | 65.2 °C |
| Solubility: | immiscible with water. |
| Appearance: | Clear, colorless liquid |
| Hazard Symbols: |
 T, Xi, C
|
| Risk Codes: | 25-37/38-41-36/37/38 |
| Safety: | 26-39-45-37/39 |
| Transport Information: | UN 2810 6.1/PG 3 |
| PSA: | 0.00000 |
| LogP: | 2.55640 |
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Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine In dichloromethane at 20℃; for 0.15h; Appel Halogenation; | 95% |
| With carbon tetrabromide; triphenylphosphine In chloroform at 20℃; for 240h; | 93% |
| With 2,2,2-tribromo-1,3,2-benzodioxaphosphole In chloroform | 86% |
Conditions
| Conditions | Yield |
|---|---|
| With water; boron tribromide In dichloromethane at 23℃; for 23h; regioselective reaction; | 87% |
| With hydrogen bromide at 170℃; im Rohr; |
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen bromide; phosphorus tribromide at 80℃; for 0.666667h; | A 85% B 4% |
| With hydrogen bromide; phosphorus tribromide at 80℃; for 0.666667h; | A 27% B 53% |
Conditions
| Conditions | Yield |
|---|---|
| With sulfuric acid; sodium bromide In water for 3h; Heating; | 84.8% |
| With hydrogen bromide at 130℃; | |
| With sulfuric acid; hydrogen bromide |
Conditions
| Conditions | Yield |
|---|---|
| A n/a B 82% |
- 873988-92-2
1,4-bis-isopentyloxy-butane
A
- 110-52-1
1,4-dibromo-butane
B
- 51748-48-2
1-bromo-4-isopentyloxy-butane
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen bromide |
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen bromide |
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen bromide |
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen bromide | |
| With hydrogen bromide at 130 - 140℃; im Rohr; |
- 31991-78-3
uvariadiamide
- 110-52-1
1,4-dibromo-butane
Conditions
| Conditions | Yield |
|---|---|
| With phosphorus pentabromide | |
| With bromine; phosphorus trichloride | |
| With phosphorus pentabromide im Vakuum; |
Raw Materials
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1,4-Dibromobutane
Consensus Reports
Reported in EPA TSCA Inventory.
Specification
1. Introduction of 1,4-Dibromobutane
1,4-Dibromobutane is a kind of Pharmaceutical intermediates, it is also called Dibromobutane; tetramethylene bromide; Tetramethylene dibromide.
2. Properties of 1,4-Dibromobutane
Melting Point: - 20 °C(lit.)
Boiling Point: 197 °C at 760 mmHg
Flash Point: 65.2 °C
Solubility: immiscible with water.
Appearance: Clear, colorless liquid
3. Toxicity of 1,4-Dibromobutane
| 1. | mmo-sat 10 µmol/plate | MUREAV Mutation Research. 141 (1984),11. | ||
| 2. | ipr-mus LD50:300 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 14 (1964),668. |
4. Safety Information of 1,4-Dibromobutane
Hazard Codes :
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C (Toxic;Irritant;Corrosive)Risk Statements :25-41-36/37/38 (Toxic if swallowed ;Risk of serious damage to eyes ;Irritating to eyes, respiratory system and skin )
Safety Statements :26-45-37/39 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) ;Wear suitable gloves and eye/face protection )
RIDADR :UN 2810 6.1/PG 3
WGK Germany : 2
RTECS : EJ7565000
6. Preparation of 1,4-Dibromobutane
1,4-Dibromobutane can be from THF via the open-loop, bromide derived. added hydrobromic acid,then add THF dropwise under stirring , and then dropping sulfuric acid,the temperature should be controlled at below 50 ℃. And then heated to 108 ℃ or so back 4h, after reaction continue stiring for 1h,when it is cold, take the subnatant,wash to neutral with soda solution, then add anhydrous calcium chloride for drying, filtration,then it is finished.
7. Use of 1,4-DIBROMOBUTANE
1,4-DIBROMOBUTANE can be used in organic intermediates.