Reference

Copolymerization of ethyl a-cyanoacrylate with dialkyl and bis(fluoroalkyl) methylenemalonates

Copolymerization of ethyl a-cyanoacrylate with dialkyl and bis(fluoroalkyl) methylenemalonates. Polyakova, A. M.; Suchkova, M. D.; Mager, K. A.; Korshak, V. V.Chemicals with cas numbers 25067-30-5 and 89174-20-9 also play role. (Inst. Elementoorg. Soedin. im. Nesmeyanova, Moscow, USSR). Vysokomol. Soedin., Ser. A, 26(1), 70-4 (Russian) 1984. CODEN: VYSAAF. ISSN: 0507-5475. DOCUMENT TYPE: Journal CA Section: 35 (Chemistry of Synthetic High Polymers) Section cross-reference(s): 38 Et a-cyanoacrylate (I) copolymd. with CH2:C(CO2R)2 [R = Et, Pr, Bu, C7H15, CH2(CF2)nH; n = 2, 4, 6] via anionic or radical mechanisms (catalysts: piperidine [110-89-4], Bu3N [102-82-9], KOH, dicyclohexyl peroxydicarbonate [1561-49-5], Bz2O2 [94-36-0]). The copolymers obtained in anionic polymn. with dialkyl methylenemalonates were enriched in I, whereas the compn. of these copolymers obtained in radical polymn. approached that of the reaction mixt. The compn. of the copolymers of I with F-contg. monomers was the same as the compn. of the reaction mixt. Radical polymn. gave copolymers in higher yields and with higher viscosities than anionic polymn. The copolymers of I with F-contg. methylenemalonates had higher hydrolytic and thermal stability than poly(Et a-cyanoacrylate) (II) [25067-30-5]. Adhesive joints prepd. from these copolymers also had better physicomech. properties that those of II. .

Synthesis and antileukemic activity of 2-(2-methylthio-2-aminovinyl)-1-methylquinolinium iodides

Synthesis and antileukemic activity of 2-(2-methylthio-2-aminovinyl)-1-methylquinolinium iodides. Foye, William O.; Kim, Young Ho; Kauffman, Joel M. (Samuel M. Best Res. Lab., Massachusetts Coll. Pharm. Allied Health Sci., Boston, MA 02115, USA).There are some reagents with their cas registry numbers 110-89-4 and 88973-11-9 are used in this study. J. Pharm. Sci., 72(11), 1356-8 (English) 1983. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 Reaction of 2-[2,2-bis(methylthio)vinyl]-1-methylquinolinium iodides with several heterocyclic aliph. amines at 30-70° resulted in replacement of one methylthio group to give the title compds. I (NRR1 = morpholino, thiomorpholino, piperidino, 4-methylpiperazino, 3-methylpiperazino, R2 = H, NRR1 = morpholino, R2 = Me). Reaction with pyrrolidine gave an unidentified product lacking sulfur. Antileukemic screening against P-388 lymphocytic leukemia showed pos. activity only with I (NRR1 = morpholino, R2 = Me) whereas I (NRR1 = morpholino, R2 = H) was inactive. This result is in contrast to previous testing results with the 2-[2,2-bis(methylthio)vinyl] compds. where both 6-substituted and 6-unsubstituted derivs. showed activity. .