Detail of "11006-31-8"

Reference

Studies on the ionophorous antibiotics

Studies on the ionophorous antibiotics. XII. Effects of ionophore lysocellin on cation distribution and respiration in mitochondria. Mitani, Mitsuaki; Koenuma, Mitsuo; Otake, Noboru (Inst. Appl. Microbiol., Univ. Tokyo, Tokyo, Japan). J. Antibiot., 30(10), 829-35 (English) 1977. CODEN: JANTAJ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The effects of the ionophore lysocellin (I) [55898-33-4] on the movements of Ca2+, Mg2+ and alkali metal cations and its effect on energy utilization by rat liver mitochondria have been investigated. I (0.05 mM) induced dissocn. of membrane-bound Ca, and an apparent steady state was established across the inner membrane between energy-linked Ca accumulation and the ionophore-induced depletion of Ca. No detectable efflux of intramitochondrial Ca2+ and Mg2+ was induced by 0.05 mM I, but the uptake of exogenously added Ca was significantly inhibited. The ionophore augmented Mg2+ release from mitochondria induced by Ca2+ addn. and also caused rapid release of K+ from mitochondria preloaded with K+ by valinomycin or monazomycin [11006-31-8]. High levels (0.5 ~ 10 mM) of I caused massive depletion of endogenous Ca2+, Mg2+ and K+ from mitochondria, resulting in disruption of mitochondrial functions including release of state 4 respiration, stimulation of ATPase and inhibition of ADP- or DNP-stimulated respiration. Structure-activity studies with chem. modified compds. of I indicated the important role of terminal carboxylic acid and C21 hydroxyl function in the activity of the ionophore, and there is a good correlation between the effect of I on mitochondrial cation movements and its ability to complex with cations detd. in an org. solvent-water two-phase partition system.

Lipid bilayer membrane electronic circuit components

Lipid bilayer membrane electronic circuit components. Muller, Robert L.; Andersen, Olaf S. (Cornell Research Foundation, Inc., USA). U.S. US 4618916 A 21 Oct 1986, 15 pp. (United States of America) CODEN: USXXAM. CLASS: ICM: H01G009-00. ICS: G11C011-00. NCL: 361434000. APPLICATION: US 84-683255 18 Dec 1984. DOCUMENT TYPE: Patent CA Section: 76 (Electric Phenomena) Section cross-reference(s): 6 Circuit components structures employing a lipid bilayer membrane are described. Elec. conductive liq. 1400-61-9 and 11006-31-8 are cas registry numbers of chemicals which are used as reagents here. phases contact both sides of the membrane. A substance which is capable of inducing voltage-dependent conductance in the membrane is present in 1 of the liq. phases. Circuit components, including a component which employs acidic solns. and which is capable of maintaining a const. charge carrier concn.; memory arrays; and methods of changing and detg. the state of a circuit component are described. Potentials of 500-1000 mV may be used to change the state of a component and potentials of 50-100 mV may be used to interrogate the component. .